Brains and Gains with Dr. David Maconi Leo Rex on Longevity, Jason Blaha & Greg Doucette, Fasting
Dec 23, 2020
Leo Rex, creator of Leo and Longevity and former strength athlete turned behavioral researcher. He discusses biological vs chronological age, genetics and centenarian traits. They cover risks of heavy lifting, anabolic use and blood pressure concerns. Conversations touch on online fitness culture, YouTube credibility, rapamycin, fasting and circadian time‑restricted eating.
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Centenarian Hotspots May Be Genetic
- Leo notes geography and genetics likely explain many centenarian hotspots more than lifestyle alone.
- He cites FOXO3A prevalence in East Asians as an example linking population genetics to longevity clusters like Japan.
Keep Strength Training Moderate For Longevity
- Balance resistance training for muscle with cardiovascular work to maximize longevity and avoid extreme heavy loads.
- Leo recommends moderate loads to preserve bone and glucose buffering while avoiding the extreme blood pressure spikes of maximal lifting.
Max Lifts Can Spike Blood Pressure Dangerously
- Heavy maximal lifts can spike systolic blood pressure extremely high, which nephrologists suspect injures kidneys.
- Leo cites measured systolic peaks up to ~400 mmHg during lifts and links powerlifting/olympic lifting to shorter cardiovascular longevity.