Siim Land Podcast

Dr Uri Alon, physicist-turned-biologist and Weizmann professor who models aging, discusses genetics, lifestyle, and luck in shaping lifespan. He explains why lifestyle adds about five years for many, when it matters most, and why fundamental aging processes set practical limits. Talks cover senescent cells, strategies to push lifespan limits, and how genes, environment, and randomness combine.

A rapid-fire ranking of 64 longevity interventions across lifestyle, medicine, geroscience and biohacking. He contrasts basics like not smoking, sleep, fiber and purpose with cutting-edge options such as metformin, rapamycin debates, senolytics and thymus work. Practical biohacks like metabolic health, creatine and omega‑3s get weighed against experimental therapies and proactive healthcare emerges as a top pick.

Dr Michael Crawford, a 95-year-old pioneer in brain chemistry from Imperial College, shares decades of DHA research. He describes how coastal seafood fueled human brain expansion. Short, lively segments cover DHA’s role in vision and behavior, pregnancy nutrition, mercury vs selenium in fish, limits of land and plant omega-3s, and urgent fixes like restoring fisheries and better maternal nutrition.

Dr. Benjamin Blue, CEO of Ora Biomedical and molecular medicine Ph.D. who builds high-throughput longevity screens. He describes a million-molecule robotic strategy using worms, notable lifespan hits and screening pipelines, common supplements that showed effects, peptide screens, AI-driven combination searches, and prospects for very large lifespan extensions.

Dr. Michael Lustgarten, exercise scientist who uses longitudinal self-tracking for personalized optimization. Dr. Brad Stanfield, practicing GP applying clinical guidelines to bloodwork. Dr. Matt Kaeberlein, biogerontologist and biotech CEO with deep aging-research experience. They debate what bloodwork can and cannot reveal. They compare top biomarkers, rate-of-change tracking, CGM use, ApoB/LDL nuance, and risks of over-targeting numbers.

A rapid tour through 100 exercises ranked for long-term health and movement quality. Short segments cover strength staples like squats, deadlifts, presses and rows. Mobility, yoga and recovery get attention alongside plyometrics, sprinting and diverse cardio options. Calisthenics skills, carries, sport activities and playful movement rounds out a longevity-focused toolkit.

A fast-paced tour of the human clinical evidence behind popular peptides. Topics include regenerative and brain-targeting peptides, growth-hormone mimetics, and aesthetic compounds. He compares Russian and Western trial data, highlights which peptides have real human trials versus only animal data, and warns about sourcing and safety concerns.

A rapid Q&A covering top health priorities and which biomarkers matter most. Discussion of VO2max, visceral fat targets, omega-3 index and keeping inflammation very low. Talks about glycine and cancer research context without alarm. Covers limits of supplements for lasting IQ gains, practical autophagy tips, plasma exchange views, injectable NAD concerns, cortisol from fasting, and mini-trampoline perks.

Dr Elie Abirached, Harvard-trained founder of Restore and creator of the Limitless Human method, blends science with practical coaching. He talks about why recovery is the foundation of progress. He explains VO2 max testing, training zones, and how to build aerobic base plus intervals. He outlines recovery tools, nutrition basics, and how to progress from beginner to advanced.

Dr. Daniel Promislow, DPhil, is a Senior Scientist and Scientific Advisor at the HNRCA. He has worked for over 30 years on the biology of aging and has published over 180 papers. Currently, he's working on the Dog Aging ProjectCheck out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:26 What is the Dog Aging Project02:26 Size and longevity in dogs06:06 Why dog ownership is associated with longevity11:06 Bon Charge sponsorship12:00 What lifestyle makes dogs live longer17:10 Diet for dog longevity19:25 Intermittent fasting for dogs24:20 Calorie restriction for dogs28:35 Exercise for dogs31:55 Rapamycin for dogs45:40 Other longevity compounds for dogs57:35 Supplements for dogsMy 2026 longevity routine: https://youtu.be/OceysodInIo100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi