Siim Land Podcast #497 The Complete Longevity Ranking: Lifestyle, Medicine, Biohacking
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Mar 22, 2026 A rapid-fire ranking of 64 longevity interventions across lifestyle, medicine, geroscience and biohacking. He contrasts basics like not smoking, sleep, fiber and purpose with cutting-edge options such as metformin, rapamycin debates, senolytics and thymus work. Practical biohacks like metabolic health, creatine and omega‑3s get weighed against experimental therapies and proactive healthcare emerges as a top pick.
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Favor Metformin For Broad Metabolic Impact
- Do Consider Metformin As A Broad Metabolic Tool Over PCSK9 For Longevity.
- Siim Land picks metformin for wider metabolic and potential anticancer benefits versus PCSK9 which primarily targets lipid/Lp(a) lowering.
Proactive Healthcare Beats Isolated Fixes
- Insight Proactive Healthcare Covers Many Single Interventions.
- Siim Land argues routine proactive care (bloodwork, scans, prevention) can subsume benefits of isolated measures like vaccinations or captopril by catching disease earlier.
Practice Moderate Calorie Restriction Safely
- Do Use Calorie Restriction Carefully To Extend Healthy Lifespan.
- Siim Land endorses moderate CR without malnutrition or frailty, combined with strength training and nutrient-dense diet to get longevity benefits seen in animal studies.