Siim Land Podcast #494 Longevity Experts Discuss Bloodwork - Panel with Dr. Brad Stanfield, Dr. Matt Kaeberlein, and Dr. Michael Lustgarten
Feb 27, 2026
Dr. Michael Lustgarten, exercise scientist who uses longitudinal self-tracking for personalized optimization. Dr. Brad Stanfield, practicing GP applying clinical guidelines to bloodwork. Dr. Matt Kaeberlein, biogerontologist and biotech CEO with deep aging-research experience. They debate what bloodwork can and cannot reveal. They compare top biomarkers, rate-of-change tracking, CGM use, ApoB/LDL nuance, and risks of over-targeting numbers.
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Avoid Overtargeting Biomarkers That Cause Harm
- Avoid aggressively targeting biomarkers without considering net harms; interventions can create unintended negative effects elsewhere.
- Brad Stanfield highlights insulin dosing for diabetes as an example where lowering A1c too much caused hypoglycemia harms.
Three Practical Blood Tests For Most People
- If limited to three blood metrics, prioritize lipid particle count (ApoB), kidney function (creatinine or cystatin C), and a full blood count for broad safety signals.
- Brad Stanfield chose ApoB, creatinine (cost) and FBC as pragmatic essentials.
ApoB Plus VLDL And Lp(a) Better Predict Risk
- Not all atherogenic particles are equal; VLDL and lipoprotein(a) can be several-fold more atherogenic than LDL.
- Michael Lustgarten cites recent research and his own repeated testing to prioritize ApoB, Lp(a) and VLDL.