Siim Land Podcast #495 Inside the Search for a 300% Lifespan Breakthrough - Dr Ben Blue
Mar 6, 2026
Dr. Benjamin Blue, CEO of Ora Biomedical and molecular medicine Ph.D. who builds high-throughput longevity screens. He describes a million-molecule robotic strategy using worms, notable lifespan hits and screening pipelines, common supplements that showed effects, peptide screens, AI-driven combination searches, and prospects for very large lifespan extensions.
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Search Outside Familiar Supplements To Find Breakthroughs
- Prioritize chemical diversity beyond known supplements and approved drugs to discover novel longevity compounds.
- Screen natural products and diverse libraries to build training data for AI-driven prediction and design.
3 Percent Hit Rate Suggests Many Untapped Longevity Compounds
- Aura's hit rate for novel compounds above 30% lifespan extension is ~3% in their unbiased screens.
- That implies many potent, previously unknown interventions exist within wider chemical space.
Test Popular Supplements Before Assuming Benefit
- Validate commonly used supplements empirically rather than assume efficacy: sulforaphane, berberine, glycine, spermidine and alpha-lipoic acid showed lifespan benefits in their worm screens.
- Use open databases and publish builds to track reproducible results.