LONGEVITY with Nathalie Niddam

Dr. John Gildea, a clinician‑researcher in detox pathways and NRF2 signaling, and David Roberts, researcher and co‑founder who developed a stabilized sulforaphane supplement after personal toxicity experience. They discuss stabilizing sulforaphane, how it influences inflammation and NRF2, microplastics and pollutant mobilization, differences between sulforaphane and glucoraphanin, and practical detox strategies.

Erin Ryan, producer and frequent collaborator who co-hosts this follow-up, helps steer a listeners' Q&A on bioregulators and peptides. They tackle cancer safety concerns, menopause and ovarian support, sourcing and quality control, and practical dosing strategies. Short, practical conversations about when to use or avoid these compounds and where to find trustworthy suppliers.

Dr. Nafysa Parpia, board-certified naturopathic doctor and director of naturopathic medicine at Gordon Medical, specializes in environmental and complex chronic illness. She discusses lead mobilization during menopause, proper chelation and detox sequencing, using herbs and bioregulators to open elimination pathways, peptide sequencing, testing pitfalls, and plasmapheresis as a tool for removing bound toxins.

Dr. Jeffrey Bland, biochemist and pioneer called the father of functional medicine, reflects on decades of work in nutrition, immune resilience, and personalized lifestyle medicine. He discusses immune aging vs boosting. He covers diet retraining the immune system, microbiome and inflammation, tartary buckwheat trials, and practical 90-day immune renewal steps.

Dr. Aimie Apigian, physician-researcher and author who studies the biology of trauma. She traces how hidden stress shapes autoimmunity, brain inflammation, and chronic survival states. Conversations cover nervous system physiology, attachment and environmental triggers, phases of healing, somatic rewiring, and building biological capacity for resilience.

Leslie Kenny, an Oxford-based longevity expert who reversed autoimmune diagnoses and founded Oxford Healthspan, shares her journey and research on spermidine and autophagy. She explores biological vs chronological age, trauma’s impact on inflammaging, thyroid misdiagnosis, practical diet and tracking changes, and how spermidine may support immune renewal and safer fasting strategies.

Dr. Natalie Yivgi-Ohana, a mitochondrial scientist and founder of Minovia Therapeutics, explores mitochondria as cellular powerhouses and hormone regulators. She discusses mitochondrial transfer and transplant therapies for rare diseases, scaling donor placenta mitochondria, and developing biomarkers. Conversations also cover metabolic flexibility, aging-related decline, stem cell energy, neuroprotection, and lifestyle supports for mitochondrial health.

Courtney Van Bussum, a biomedical engineer and longevity entrepreneur, explains NAD biology and why precursors or IVs can fail without system support. Short segments cover NAD/NADH balance, enzymes like CD38 and NNMT, methylation costs, and how 1-MNA can help. They also discuss when NAD infusions are useful, measuring NAD strain, and lifestyle and ketone strategies for cellular resilience.

Dr. Cynthia Keller, a pediatrician turned integrative-functional clinician who founded Centered in Wellness, discusses post-COVID nutrient depletion and its effects on mood, energy, and unexpected weight gain. She explains patterns like tryptophan and cofactor loss, gut and microbiome disruption, practical symptom-based nutrient trials, and why longer visits, listening, and family-wide approaches speed recovery.

Cathy Eason, nitric oxide and vascular health expert focused on midlife women, explains why falling estrogen in menopause harms blood flow and resilience. She highlights subtle signs like fatigue and brain fog. Short, actionable talks cover tracking vitals, wearables as feedback, diet, and a daily nitric oxide–support approach to protect heart and cognitive function.