LONGEVITY with Nathalie Niddam #418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum
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Mar 6, 2026 Courtney Van Bussum, a biomedical engineer and longevity entrepreneur, explains NAD biology and why precursors or IVs can fail without system support. Short segments cover NAD/NADH balance, enzymes like CD38 and NNMT, methylation costs, and how 1-MNA can help. They also discuss when NAD infusions are useful, measuring NAD strain, and lifestyle and ketone strategies for cellular resilience.
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Courtney Returned To Longevity During COVID
- Courtney grew up in a longevity clinic family, studied biomedical engineering, then entered startups and returned to longevity during COVID.
- COVID pulled her back to clinic ops and inspired Longevity Launch Labs to bridge clinic science and business.
Support Conversion Steps When Using NAD Precursors
- Don’t assume oral precursors or IV NAD directly become intracellular NAD; they require extracellular conversion and multi-step uptake.
- NMN converts to NR extracellularly, NR enters cells, rebuilds to NMN then to NAD, so support conversion steps not just dosing.
Avoid Chronic NAD Overdosing Without Blocking Drains
- Avoid chronic high-frequency NAD infusions or stacking IVs, sub‑Q and precursors without addressing drains like CD38/NNMT.
- Overloading NAD inputs can disturb redox balance and potentially fuel energy-hungry senescent or pathological cells.