LONGEVITY with Nathalie Niddam #420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny
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Mar 13, 2026 Leslie Kenny, an Oxford-based longevity expert who reversed autoimmune diagnoses and founded Oxford Healthspan, shares her journey and research on spermidine and autophagy. She explores biological vs chronological age, trauma’s impact on inflammaging, thyroid misdiagnosis, practical diet and tracking changes, and how spermidine may support immune renewal and safer fasting strategies.
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Eliminate Triggers Then Test Before Reintroducing Foods
- Remove common dietary triggers like gluten, dairy, and eggs if inflammatory markers are high, then retest and reintroduce cautiously.
- Use zonulin and other gut tests to confirm intestinal permeability before attributing wide food sensitivities.
Emotional Healing Is Integral To Physical Recovery
- Trauma therapy and emotional closure are essential components of physical recovery, not optional extras.
- Leslie used letter-writing, burning letters, visualization, and uterine massage as part of mind-body healing.
Use Basal Temperature And Pulse To Guide Thyroid Care
- Track simple clinical signs for thyroid function: five-day morning basal body temperature and resting pulse to detect hypothyroid symptoms missed by standard blood ranges.
- Use symptom-guided titration (e.g., basal temp ~37.6°C) when working with an informed clinician.
