The Diary Of A CEO with Steven Bartlett David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!
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Mar 23, 2026 
David Sinclair, Harvard genetics professor and longevity researcher, dives into whether aging can be treated like a disease. He explores human trials aimed at resetting biological age, gene therapy for restoring eyesight, the idea that cells lose vital instructions over time, plus fasting, exercise, and supplement routines linked to longer healthspan.
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Treat Cholesterol Early And Build Meals Around Longevity Foods
- Get LDL and especially Lp little a checked early, and lower them through diet, medication, or both if elevated.
- Sinclair has taken statins since age 30 and highlights olive oil, nuts, avocados, and cruciferous vegetables as supportive foods.
Pulse Some Longevity Compounds Instead Of Taking Them Daily
- Cycle certain longevity compounds instead of taking everything daily, especially around workouts.
- Sinclair says resveratrol helped mice more when pulsed every second day, and metformin can blunt exercise performance if timed poorly.
Start With Meal Skipping And Breathless Cardio
- Prioritize meal-skipping and breathless cardio if you want the biggest lifestyle return for longevity.
- Sinclair says strength training matters too, but he especially wants at least five minutes of panting three times weekly.
