The Ready State Podcast

Evidence-Based Wellness Without the “Protocol Life” — Practical Longevity & What to Track with Dr. Rachele Pojednic

26 snips
Feb 19, 2026
Dr. Rachele Pojednic, a Stanford faculty member and evidence-based wellness researcher, offers a grounded take on longevity. She dismantles rigid “protocol life” thinking. Short, practical science-backed topics include what to track (A1C, fasting glucose, lipids, resting HR), limits of wearables and HRV, Zone 2 reality, supplement safety, and how to build one small, sustainable habit.
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INSIGHT

Protocols Often Harm More Than Help

  • The obsession with perfect protocols harms real health because life is messy and individual data is limited.
  • Rachele Pojednic urges people to relax and prioritize sustainable habits over chasing optimization fads.
ANECDOTE

From Frustrated Researcher To Industry Trojan

  • Rachele chased CBD research but IRBs refused due to regulatory gray zones, despite public availability.
  • She accepted a Restore Labs role to run rigorous studies with contractual independence to avoid rubber‑stamping claims.
INSIGHT

Wearable Metrics Lack A Common Language

  • Wearables measure different things and often disagree on sleep stages and recovery scores.
  • Rachele argues we need a common diagnostic suite so metrics are comparable and actionable.
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