The Gabby Reece Show Your Microbiome, GLP-1 & Next-Generation Probiotics | Dr. Colleen Cutcliffe
Mar 9, 2026
Dr. Colleen Cutcliffe, microbiome scientist and Pendulum co-founder, translates gut bacteria research into practical products. She explores how microbes shape metabolism, GLP-1 signaling, cravings, hormones and perimenopause. Conversation highlights next-generation probiotics, resilience-building strategies, travel and antibiotic impacts, and sensible ways to start rebuilding gut health.
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Gut Microbes Drive Natural GLP-1 Production
- Certain gut microbes stimulate the body's natural GLP-1 hormone, which regulates glucose and cravings.
- People with diabetes often lack these microbes, so replacing them can restore GLP-1 signaling instead of relying only on drugs.
Start Microbiome Repair With Food First
- Start microbiome support with diet: prioritize produce, spices, and beans to feed beneficial microbes before trying supplements.
- Nutrition is the second most potent microbiome changer (after antibiotics), so 'free lunch' brings employees back to the line.
Run Supplements As A 90 Day Experiment
- Treat probiotics or any microbiome supplement like an experiment: keep other variables constant, test for effects, and give it 90 days to judge benefit.
- If no change after 90 days, do a washout and try another approach.
