The Jesse Chappus Show

Dr. Dale Bredesen, neurologist and researcher who developed a precision medicine protocol for cognitive decline, explains why Alzheimer’s may be preventable and even reversible. He reviews randomized trial results, reframes amyloid’s role, and outlines testing and metabolic strategies. Practical prevention steps, detox concerns, and how to start a systematic assessment are highlighted.

Michelle Hurn, registered dietitian, ultrarunner and author, shares her clinical and personal low-carb journey. She dissects how high-carb, ultra-processed diets drive silent metabolic decline and why fasting insulin matters. She recounts professional pushback, adapting ultra-running on fat oxidation, safe low-carb starter tips, and practical carbohydrate targets for health and sport.

Dr. David Brownstein, a board-certified family physician and iodine authority, shares clinical stories and protocols. He debunks iodine myths and traces population declines. He explains forms, dosing, testing, and safety, plus interactions with halides, thyroid conditions, cancer cases, pediatric care, pregnancy, and adjunct nutrients.

Belinda Fettke, an independent researcher who probes how industry and ideology shape dietary advice. She digs into conflicts behind nutrition guidelines and exposes the commercial and institutional forces shaping the Blue Zones story. The conversation covers origins of Blue Zones claims, nuanced regional diets, and how longevity narratives get packaged and sold.

Dr. Jason Fung, nephrologist and bestselling author who studies fasting and insulin, breaks down why hormones—especially insulin—drive fat, not calories. He compares food forms, explains how meal timing, snacking, and ultra‑processed foods alter insulin, and offers practical low‑insulin tactics like meal order, resistant starch, and fasting. He also covers hormones that set defended body weight.

Dr. Roger Seheult, quadruple board-certified physician and MedCram co-founder, explains sunlight beyond vitamin D. He breaks down ultraviolet, visible, and infrared effects. He covers safe UV timing, morning light for circadian health, light therapy options for winter, and how infrared boosts mitochondrial function. Practical tips for brief morning sun and indoor light choices are highlighted.

Joel Brind, Yale-trained life scientist who researches glycine and inflammation. He shares why he began high-dose glycine, rodent lifespan findings, how glycine targets methionine metabolism and immune cells, surprising self-experiment results where injuries did not inflame, practical dosing tips, and anecdotes on glycine’s effects for sleep, itch, gout, and COVID outcomes.

Dr. Andrew Koutnik, an award-winning metabolic researcher and ketogenic-diet expert, explains why most adults are metabolically unhealthy. He covers how obesity and insulin dysregulation develop, who may benefit from low-carb or keto approaches, practical early warning signs to watch, and realistic steps—diet, movement, sleep—to improve metabolic resilience.

Dr. Scott Sherr, a board-certified internist and hyperbaric/health optimization expert known for methylene blue research. He traces methylene blue’s history, explains how it supports mitochondria and performance, covers dosing, administration routes, safety concerns like MAOI effects, and practical product and timing tips. Short, practical guidance on when and how people might trial it.

Dr. Sarah Myhill, a physician specializing in chronic fatigue and metabolic health, sheds light on the epidemic of metabolic dysfunction caused by ultra-processed foods. She champions a meat-heavy, low-carb diet for achieving ketosis, dives into the benefits of organ meats, and explains how excess sugars lead to systemic inflammation. Sarah also discusses gut health and its connection to weight gain, while offering practical advice on hydration, supplementation, and the rapid benefits of dietary changes. Her insights are a must-listen for anyone interested in optimizing their health.