The Jesse Chappus Show 697: Alzheimer's Is Now Optional — The Research That Changes Everything | Dr. Dale Bredesen
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Mar 24, 2026 
Dr. Dale Bredesen, neurologist and researcher who developed a precision medicine protocol for cognitive decline, explains why Alzheimer’s may be preventable and even reversible. He reviews randomized trial results, reframes amyloid’s role, and outlines testing and metabolic strategies. Practical prevention steps, detox concerns, and how to start a systematic assessment are highlighted.
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Screen With Blood P‑tau Not Routine PET Or Spinal Tap
- Check blood P‑tau (and GFAP/NFL) instead of PET or lumbar puncture for routine screening.
- Use NeuroCode P‑tau thresholds: <0.34 normal, 0.34–0.47 intermediate, 0.47–0.63 concerning, ≥0.63 likely amyloid — recheck every ~5 years.
Remove Insults Before Attempting Amyloid Removal
- Don't rush to remove amyloid with antibodies; first remove ongoing insults and reduce inflammation.
- After 6–12 months of precision care, consider gentle, gradual amyloid reduction (e.g., curcumin or microdosing antibodies) to avoid microhemorrhages.
Start Prevention Testing At 35 With A Targeted Panel
- For prevention get a focused test bundle: inflammation, methylation, lipids, fasting insulin, sleep metrics, and P‑tau.
- Bredesen recommends starting prevention testing from age 35 and rechecking P‑tau about every five years.
