This Week in Virology

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier Vincent, Alan, Rich, and Dickson review influenza vaccines. Links for this episode: FDA licensed flu vaccines Seasonal influenza vaccine distributed How flu vaccine strains are selected (one, two) WHO report on flu vaccine strain selection (pdf) Derek Smith on antigenic mapping Salk's 1945 influenza vaccine TIV preparation: Fluzone, Agriflu, Fluvirin, Fluarix, Flulaval, Afluria (pdfs) LAIV preparation (pdf) Efficacy of flu vaccine 2012-13 (MMWR, virology blog) Meta-analysis of flu vaccine efficacy (Lancet) Two new flu vaccines FDA approved Flublok Flublok clinical trial Pandemrix and narcolepsy (Yahoo, PLoS One, PLoS One) CIDRAP analysis of flu vaccines Letters read on TWiV 217 Weekly Science Picks Rich - Repoopulate (original article), Robogut (new clinical trial)Alan - WTF, Evolution?Dickson - The Beauty and Benefits of ScienceVincent - Supercomputing modeling of poliovirus Listener Pick of the Week Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export. Links for this episode: Slides for this episode (pdf) Spliced Ad 2 late mRNAs (Cell) An amazing sequence arrangement (Cell) Adenovirus late mRNA undecanucleotide (Cell) Aaron Shatkin, 72 (virology blog) Schrödinger's cat (Wikipedia) Letters read on TWiV 216 Weekly Science Picks Rich - Linus Pauling's explanation of science (YouTube)Alan - Underwater experimentsKathy - I'm a virus (YouTube)Vincent - Stem cells (Bizarro Comics) Listener Pick of the Week Tom - The President's AnalystDanielle - Overly honest methods (HuffPost and ASBMB Today) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East. Links for this episode: Neuronal survival after rabies virus infection (PLoS Path) Clusters of coronavirus cases (Nature) ProMedMail on novel coronavirus Novel coronavirus outbreak news (Int J Inf Dis) Genomic characterization of novel coronavirus (mBio) Broad cell tropism of novel coronavirus (mBio) Are viruses alive? (poll at virology blog) Antibodies taken up by endocytosis (PNAS) Antibody eliminates alphaviruses from neurons (Science) Image: Virus in the garden by Helen Hache Letters read on TWiV 215 Weekly Science Picks Alan - I'm a Scientist - The FilmKathy - Humorous units of measurement (Wikipedia)Vincent - Open access must enable open use (Nature) Listener Pick of the Week Tarwin - Plague Inc. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons. Links for this episode: Coagulation factor X activates innate immunity to adenovirus (Science) A decorated virus cannot hide (Science) Reflecting on goals for Science Polyomavirus associated with raccoon brain tumors (EID) MPNST Moore tumor viruses - TWiV 160 Treating CLL with lentivirus vectors (NEJM) Letters read on TWiV 214 Weekly Science Picks Alan - Parasite of the DayKathy - Tour of International Space StationVincent - Earth as Art Listener Pick of the Week Robin - Angell on Big PharmaMichael - Flu jokesJim - Database of Ted talks; Downloadable Ted Talks Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012. Twelve virology stories from 2012: H5N1 (TWiV 190, 182, 177, 173, 168) Polymorphisms that control susceptibility (TWiV 175, 180) New virus receptors (TWiV 166, 210) XMRV: Last nail in the coffin (TWiV special) Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog) Biomedical research crisis (TWiV 208, 184, 189, 194) Polydnaviruses in parasitoid wasps (TWiV 179) Carolyn Coyne’s placental barrier story (TWiV 193) Touring NEIDL (TWiV 200) Epidemiology (TWiV 169, 178) A good year for virus hunting (173, 183, 195, 196, 198, 199, 204) Pox accordion (TWiV 198) Links for this episode: US plans for H5N1 research (ScienceInsider) FDA recommends against Ampligen Rituximab and CFS (PLoS One) No evidence for XMRV in prostate cancer (PLoS One) Retraction of XMRV prostate cancer paper (Retraction Watch) Gender bias among science faculty (PNAS) NEIDL risk assessment Virology 101 at TWiV Letters read on TWiV 213 Weekly Science Picks Rich - Our Mr. Sun (IMDB entry) (wiki)Alan - PubReader from NCBI announcement and instructionsKathy - Popular Mechanics 110 picks for the next 110 yearsVincent - 366 days: Nature's 10 Listener Pick of the Week Matt - The flu vaccine controversy Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Stuart Firestein Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science. Links for this episode: Ignorance: How it drives Science by Stuart Firestein Ignorance website Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more. Links for this episode: TWiV 116: Cocaine, colonies, and chickens Glofish Recombinant Hendra vaccine Gene therapy for color blindness (Nature) FDR, polio, and Guillain-Barré Transcript of TWiV 197: Philip Marcus (pdf) TWiV 10: Bats, elephants, and AIDS TWiM 6: Phage therapy TWiP 47: For whom the trich tolls Viruses of protozoan parasites (virology blog) Long in the tooth Transcript of 'How to read a science paper' (pdf) FEMA disaster preparedness courses Letters read on TWiV 212 Weekly Science Picks Rich - OverviewAlan - Notes towards the complete works of ShakespeareKathy - Correlation vs. Causation (#1, #2, #3)Vincent - Periodically inspired Listener Pick of the Week Mark - Life of a Nature paperRicardo - Things don't go viral Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA. Links for this episode: mRNA vaccine against influenza (Nat Biotech) Phage tubulin assembles dynamic filaments (Cell) Viral skeleton (The Scientist) Not unorganized bags of enzymes (TWiM 28) Bacterial cytoskeleton (FEMS Micro Rev) Triangulation number (jpg) Letters read on TWiV 211 Weekly Science Picks Rich - Ocean Global Shark TrackerAlan - The Field Book ProjectKathy - How to manipulate an army of zombiesVincent - Science sculpture Listener Pick of the Week Stephen - WEHI.TV Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA. Links for this episode: HBV and HDV cell receptor (eLIFE) Getting to grips with hepatitis (eLIFE) Sodium taurocholate Poliovirus hijacks DNA repair enzyme (PNAS) Letters read on TWiV 210 Weekly Science Picks Rich - Vendée GlobeDickson - Earth at nightAlan - Trophée Jules VerneKathy - Science cookiesVincent - Trilobite Glassworks Listener Pick of the Week Ken - Spanish flu pandemic model (teacher's guide)Jim - Santa Cruz Science Communication Program (also see SHERP) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more. Links for this episode: Postcard from the ultimate student athlete (pdf) Fidelity of protein synthesis (Biochemistry, 5th ed.) Letters read on TWiV 209 Weekly Science Picks Dickson - Cassini web site and Mars reconnaissance orbiterAlan - OneZoom Tree of LifeKathy - Viral tumor suppressor structure (Cell)Vincent - Spot the Station Listener Pick of the Week Ricardo - Once upon a time: The possible story of virusesJim - Encode, myIDP, Experiment Reproduction podcastsMark - MoMath Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv