This Week in Virology

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus. Links for this episode: Containment plan for poliovirus (pdf, WHO) Post-eradication of polio Ocular tropism of respiratory viruses (MMBR) Rally for medical research HeLa genome sequence withdrawn (ScienceInsider) Immortal life sequel (Rebecca Skloot) HeLa genome sequence published, withdrawn (virology blog) Vial of Guanarito virus missing (ABC news) Human H7N9 infections (ProMedMail) WHO H7N9 updates China escalates H7N9 response (NY Times) Brian Kimble on H7N9 Compatibility of H9N2 and H1N1 genes (PNAS) Letters read on TWiV 227 Weekly Science Picks Kathy - NIAID YouTube videosAlan - Lego insectsRich - How to see the world in a grain of sandVincent - Vaccines, viruses, and the anti-vax movementDickson - Edinburgh Science Festival Listener Pick of the Week Stephen - Nature iOS appMehul - Voices for vaccines Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody Vincent and Dickson speak with Terry Dermody about his career in medicine and virology. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more. Links for this episode: Plant viruses alter insect behavior (Sci Rep) Circovirus in Shanghai Letters read on TWiV 225 Weekly Science Picks Kathy - Case stories about CoV-EMC (one, two)Rich - The Self-Illusion by Bruce HoodVincent - Moving Targets Listener Pick of the Week Liam - eLIFE and RubriqSteve - Plant virus ecology (mp3)Neil - World Immunization Week Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract. Links for this episode: Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature) Receptor for new coronavirus (Nature) Broad reception for coronavirus (Nature) SARS 10th anniversary (Science) Interferon-epsilon protects female reproductive tract (Science) Families fighting flu (YouTube) Monitoring infections with online data (TWiM 41) Natalie Portman was a scientist (NY Times) Letters read on TWiV 223 Weekly Science Picks Kathy - 2013 Intel Science Talent Search awardsAlan - Krebs Cycle Rap (CDC)Vincent - Jetpens (favorite one and two)D ickson - Rabies death in organ recipients (CDC) Listener Pick of the Week Justin - The DNA StoreJim - Massive Open Online ClassroomsChris - Feedly Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells. Links for this episode: International Women's Day 2013 Condit Dam, 6 weeks later (Vimeo) Influenza HA assay Covalent influenza NA inhibitors (ScienceExpress) Defective influenza HA mutants (Virology) New flu drug (BBC, e! Science) EEEV antibody, RNA in snakes (Am J Trop Med Hyg) EEEV (CDC) Zoonotic potential of CoV-EMC (mBio) CoV-EMC update (ProMedMail, CDC) CoV-EMC travel update (CDC) Letters read on TWiV 223 Weekly Science Picks Kathy - Finkbeiner test and Women in ScienceAlan - New flu vaccine efficacy study (CDC)Vincent - Threading the NEIDL video Listener Pick of the Week Steve - Prof. Joan Steitz on viral RNAEd - Archiving history of molecular biology: Press release, video, CSHL archives and videos Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor. Links for this episode: Zhijian J. Chen (Wikipedia) Sensing the dark side of DNA (Science) cGAMP is an endogenous second messenger (Science) cGAMP synthase is a DNA sensor (Science) Pore-forming toxin (Wikipedia) Letters read on TWiV 222 Weekly Science Picks Kathy - Graphene batteriesAlan - How do we get cures? (YouTube)Rich - Explosive breach of Condit Dam (Vimeo)Vincent - 10 things you can do to support open access (Tree of Life) Listener Pick of the Week Mark - The real story of StuxnetJohn - D-connector virus Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV. Links for this episode: Human transmission of SFTSV (JID) SFTSV serosurvey (EID) SFTSV on TWiV 147 SFTSV in Japan (ProMedMail) SFTSV mouse model (PNAS) SBV infectious DNA and mouse model (PLoS Path) SBV in Sweden (ProMedMail) Letters read on TWiV 221 Weekly Science Picks Kathy - Winners, 2012 Science & Engineering Visualization ChallengeVincent - The Operator and Dr. Oz's Problem Listener Pick of the Week Shane - OpenPCRJohn - Python Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk. Links for this episode: Influenza splicing regulates infection (Cell Reports) Reporting on flu splicing from NPR, BBC, NBC Splicing of influenza RNA 8 (jpg) Bacteriophage T7 remodeling during infection (Science) Cryo-ET of intact cells (Trends Cell Biol) T7: The Movie (YouTube) Cry0-EM vs Cryo-ET (Wikipedia) Virus caught in the act (e! Science News) Letters read on TWiV 220 Weekly Science Picks Kathy - Journal of Virology Image GalleryRich - Phage T7 Genetics and Physiology and slab gelsAlan - PeerJ (press release)Vincent - Virologia en Español Listener Pick of the Week Dave - Thingiverse pathogens and proteins Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases. Links for this episode: Fauci history (J Clin Inves) Fauci Pharmacy Anthony Fauci (Wikipedia) Anthony Fauci: Unfinished business (Lens) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response. Links for this episode: Kuan-Teh Jeang, 54 Resurrection of ERVs (Nature) Toll-like receptors control ERVs (Immunity) Retroviral danger from within (Immunity) Ancient viruses wreak havoc (The Scientist) Letters read on TWiV 218 Weekly Science Picks Welkin - Viruses: Essential Agents of Life (review at STC)Alan - Infinity ImaginedVincent - Spaceship built for son Listener Pick of the Week Amanda - Written? Kitten!Kevin - Protein synthesis: An epic (YouTube)Daria - The Baltimore Scheme Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv