This Week in Virology

Hosts: Vincent Racaniello and Rich Condit Guest: Michael Emerman Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis. Links for this episode: Ancient origins of SIV (PLoS Path) Paleovirology (PLoS Biology) Harmit Malik on TWiV 205 Sara Sawyer on TWiV 193 Listener Pick of the Week Molly - Facts in the case of Dr. Andrew Wakefield Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection. Links for this episode: Ultraprotective influenza vaccine in mice (PNAS) Vectored immunoprophylaxis of influenza in mice (Nat Biotech) Intranasal antibody gene transfer protects agains influenza (Sci Transl Med) Estimating influenza associated deaths (CDC) Multistate HAV outbreak (CDC) Subscribe to Microbeworld video (YouTube) Save podcasting (EFF) Letters read on TWiV 236 Weekly Science Picks Alan - Psychology of antivaccinationistsVincent - Virology on CourseraKathy - Meteorites through the ages Listener Pick of the Week Basel - Self-medication in animalsSheryl - Noadi's artFelicity - Survival of the Sickest by Sharon Moalem Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta. Links for this episode: Li Ka Shing Institute of Virology Alberta Heritage Foundation for Medical Research Raised on a farm (YouTube) Vaccinia virus strains in Dryvax vaccine (J Virol) Vaccinia DNA polymerase and recombination (J Virol) Picornavirus hijacks cell membrane (Nature) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Kathy Spindler Guests: Nels Elde and Tom Shenk Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome. Links for this episode: A cross-species view on viruses (Curr Op Virol) Pox has got a squeeze box (TWiV 198) Saturated fatty acids needed for CMV (PLoS Path) CMV and HSV metabolomes differ (PLoS Path) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus. Links for this episode: Aerosol transmission of H1N1 x H5N1 reassortants (Science) It's good science (virology blog) Viral engineering dangers (Nature) Colorblind web page filter Influenza H7N9 update (ProMedMail) Influenza H7N9 risk assessment (WHO, pdf) Influenza H7N9 confirmed cases (WHO) New coronavirus gets a new name (ScienceInsider) Novel coronavirus infection update (WHO) Coronavirus infections (WHO) Letters read on TWiV 233 Weekly Science Picks Alan - Space Oddity (YouTube)Rich - Walk through giant colonVincent - Transport proteinsKathy - Vomiting Larry (YouTube) Listener Pick of the Week Tom - US patent system is broken (DailyTech) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates. Links for this episode: University of Minnesota virology timeline Revisiting HIV-1 lethal mutagenesis (Trends Micro) Exploiting HIV-1 drug repositioning (J Virol) 5-azaC induces HIV-1 lethal mutagenesis (J Virol) HIV-1 fitness and mutation rate (J Mol Biol) APOBEC3 mutagenesis in breast cancer (Nature) Restriction factors of HIV (J Biol Chem) Nectin-4 is epithelial measles receptor (Nature) Photographs of this episode: Click here Video of this episode - YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents. Links for this episode: Canine hepacivirus (TWiV 137) Rodent homologs of hepaciviruses and pegiviruses (mBio) Bats are a reservoir of hepaciviruses and pegiviruses (PNAS) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus. Links for this episode: Francois Jacob dies (The Loom) WHO updates on H7N9 H7N9 is unusually dangerous (ScienceInsider) H7N9 case imported into Taiwan No H7N9 in poultry farms (Xinhua) Supreme Court considers gene patents (TheScientist, Nature) Patent my jeans, not my genes (Michael Wosnick) Receptor binding by ferret transmissible H5 virus (Nature) Microscale thermophoresis and bio-layer interferometry (Wikipedia) Letters read on TWiV 230 Weekly Science Picks Alan - World Science FestivalRich - 3 years of the sun in 3 minutesVincent - The Origin of AIDS by Jacques PepinKathy - Wringing out a wet washcloth in space (YouTube) Listener Pick of the Week Mark - Will it blend? (iPhone app)Marianne - Enjoy your Cells Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus. Links for this episode: Hilary Koprowski, 96 (NY Times) Koprowski, Kessin, Racaniello photo Listen to the Music by Roger Vaughan Influenza ocular infections (one, two) H7N9 global concerns (NEJM) Human infection with H7N9 (NEJM) WHO Global Alert and Response, H7N9 Avian influenza A(H7N9) virus (WHO) Novel H7N9 reassortant, implications for Europe (Eurosurveill) Genetic analysis of H7N9 (Eurosurveill) H7N9 compared with H7N7 outbreaks (Eurosurveill) Image credit: Eurosurveillance Letters read on TWiV 229 Weekly Science Picks Alan - Nature PastCastRich - How dengue does itVincent - Squeaky Squeegee Art by Deb SklutDickson - Agritecture Listener Pick of the Week Mike - Chemistry in its element: Elements and Compounds Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus. Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay. Links for this episode: RNA element in IL-6 confers SOX resistance (J Virol) Dual uORFs regulate herpesviral translation (PLoS Path) Common viral strategy for RNA degradation (J Virol) KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path) Dengue treatment with Fc null antibodies (PLoS Path) Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis) Intrahuman dengue virus diversity (J Virol) Dynamics of dengue disease severity (Sci Transl Med) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv