This Week in Virology

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Special guest: Ian Lipkin Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus. Links for this episode: MERS-CoV in bats (EID) Mystery virus (NY Times) Part of MERS-CoV found in bat (virology blog() T. perforatus Frag virus (Virol J) Even Nature got it wrong! (Nature) Bats: Important reservoirs of emerging viruses (Clin Micro Rev) Letters read on TWiV 247 Weekly Science Picks Kathy - Rainbows explained (Frazz)Alan - Challenge.govVincent - 23andmeRich - Spot the station Listener Pick of the Week Frank - Pacifier cleaning practices and risk of allergy development (Pediatrics) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence. Links for this episode: Pandoraviruses (Science) Unlike anything seen before (virology blog) H7N9 gain of function experiments planned (Nature, Science) Virologists plan H7N9 gain of function experiments (virology blog) Creating a deadly virus? Not!! (USA Today) HeLa cell genome sequence (Nature) NIH Director explains HeLa agreement (Nature) HeLa deal (Nature) Biospecimen policy (Nature) Sequencing HeLa the right way (turbidplaque) Skloot on HeLa deal (The Scientist) HeLa deal (NY Times, USA Today) Picture on Condit's wall (EID) Letters read on TWiV 246 Video of this episode - view below or at YouTube Weekly Science Picks Kathy - GeoGuesserAlan - From one, many (YouTube)Vincent - Dave Bhella: The Wildy Award Talk (Microbeworld video)Rich - 1981 primitive internet report (YouTube) Listener Pick of the Week CN - How the Mind Works by Steven Pinker Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka The authors of the popular textbook Principles of Virology discuss how the book was conceived and written. Links for this episode: Principles of Virology Lahiere's General Virology by SE Luria Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Alan Dove Guests: Dan Barouch and Jeff Teigler This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines. Links for this episode: Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis) Seroepidemiology of adenovirus serotypes (Vaccine) SIV infection associated with expansion of gut virome (Cell, TWiV #204) Global approach to HIV-1 vaccine development (Immunol Rev) Innate cytokine responses to adenoviruses (J Virol) microRNAs as mediators of viral evasion (Nat Immunol) Letters read on TWiV 244 Weekly Science Picks Jeff - Science in the News; How to succeed in science (part one and part two)Alan - Nanostructure flowersVincent - Scientific culture Listener Pick of the Week Basel - The sequester blues Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Rebecca Dutch and Christiane Wobus On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses. Links for this episode: TWiV 143 with Stephanie Karst American Society for Virology Mouse model for human norovirus (mBio) Paramyxovirus fusion (Viruses) Photo credit: Matt Evans Weekly Science Picks Kathy - Shuffling cardsVincent - Dave Bhella - Electron cryomicroscopyRich - Seven-year postdoc Listener Pick of the Week Judi - Reading for science literacy Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein. Links for this episode: Dual virus-host arms race (PLoS Biology) Dual virus-receptor duel (see comments - virology blog) Ferritin and transferrin (Protein Data Bank) Money for nothing (YouTube) Letters read on TWiV 242 Weekly Science Picks Dickson - Mantid imagesKathy - No email? (phd comics)Alan - The turbid plaqueVincent - AAM Faq: West Nile VirusRich - Science is awesome Listener Pick of the Week Luis - Public Health Image LibraryStephen - Hopkins closes graduate science-writing program Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933. Links for this episode: Human placental trophoblasts confer viral resistance (PNAS) Placental circulation (Wikipedia) Ovum in uterine decidua (Wikipedia) A virus obtained from influenza patients (Lancet) 80 years ago today (the guardian) Influenza: Exposing the true killer (J Exp Med) Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Joe - Grand challenges in science education (Science)Mark - Weather Underground Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Markus Thali and Jason Botten Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus. Links for this episode: MERS-CoV update (WHO) MERS-CoV evolution (epidemic) Sick camel linked to MERS-CoV death (7Days) MERS-CoV hospital outbreak (NEJM) MERS-CoV French hospital cluster (Lancet) MERS-CoV family cluster (NEJM) Matt on MERS-CoV on the Voice of Russia Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells. Links for this episode: Slides for this episode (pdf) T7 ribosomal binding sites (CSH Symp Quant Biol) Tinkering with translation (CSH Persp) Translation at nexus of infection and immunity (Cell Host Microbe) Viral subversion of protein synthesis machinery (Nat Rev Micr) Weekly Science Picks Kathy - Vaccine-preventable outbreaksRich - To Catch a Virus by John Booss and Marilyn J. AugustVincent - This is Water by David Foster Wallace Listener Pick of the Week Jon - Confessions of a converted lecturer by Eric MazurPeter - FameLab Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv