The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
61 snips
Feb 10, 2026 • 59min
The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413
Dylan Gemelli, a biohacker and researcher from a bodybuilding background, breaks down peptides, SARMs and gray-area research chemicals. He explains why legality does not equal biology. Short, candid segments explore MK-677, SARMs potency and risks, low-dose nicotine for cognition, and how underground tools intersect with longevity and performance.
99 snips
Feb 8, 2026 • 10min
Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412
They dig into why muscle decline accelerates after midlife and how cellular energy loss drives fatigue and weakness. The conversation covers mitophagy, the cellular cleanup process that falters with age. They highlight urolithin A as a compound that can trigger mitophagy and discuss a bioavailable supplement version. Finally, they stress combining supplementation with resistance training, protein, and sleep.
70 snips
Feb 6, 2026 • 7min
Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411
A wide-ranging look at how trust in longevity advice can crumble when high-profile figures are implicated. The first human trial of partial epigenetic reprogramming in the eye moves gene therapy from theory toward clinical testing. Wearable continuous ketone monitors and dual glucose-ketone devices promise real-time metabolic tracking. Discussion also covers tiny wireless brain implants, expanding access to generic GLP-1 drugs, and practical muscle-preserving strategies.
121 snips
Feb 5, 2026 • 59min
Why 18-Year-Olds Wake Up Fresh (And You Don't) : 1410
Christian Drapeau, neuroscientist and founder/CSO of STEMREGEN, studies how to wake up your body’s own stem cells. He explains why stem cell decline drives fatigue and aging. Short talks cover why injected cells often fail, how fasting and exercise mobilize endogenous stem cells, the role of mitochondria and exosomes in repair, and practical stacking for better recovery and less scarring.
224 snips
Feb 3, 2026 • 1h 17min
STOP Intermittent Fasting If You Want to Stay Young : 1409
Valter Longo, a gerontology professor who leads longevity research at USC and IFOM, explains why short fasts can mislead about lifelong aging. He contrasts intermittent fasting with multi-day fasting, dives into fasting-mimicking diets, protein and amino acid tradeoffs, stem cell regeneration, mTOR/IGF-1 dynamics, and why cycling and refeeding matter for long-term balance.
45 snips
Feb 1, 2026 • 8min
Aging Starts In Your Legs (Here’s The Fix) : 1408
They argue that functional aging begins with weakening legs and discuss why leg muscles and mitochondria are central to early decline. They explain mitophagy, how it falters with age, and why exercise and protein alone can fail after your 40s. They cover how a compound called urolithin A reactivates mitochondrial cleanup, limits of gut production, and clinical studies showing strength improvements over months.
79 snips
Jan 30, 2026 • 1h 4min
The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407
Chris Burres, founder and chief scientist of MyVitalC and an early C60 manufacturer, explains the Nobel Prize molecule that reshaped longevity research. He traces its surprising 90% lifespan result in rats, how stable manufacturing made human use possible, and how C60 interacts with mitochondria, sleep, oxidative stress, and athletic recovery. Short timelines for focus, sleep, and systemic effects are discussed.
84 snips
Jan 29, 2026 • 1h 7min
Meet the Governor Who Wants Humans to Become Cyborgs : 1406
Zoltan Istvan, transhumanist author and futurist who ran for California governor, pushes radical human enhancement through tech and policy. He explores classifying aging as a disease, machine integration versus biology, implants and 3D‑printed organs, and using California as a longevity test bed. They also debate regulation, morphological freedom, AI risks, and the ethics of upgrading humanity.
80 snips
Jan 27, 2026 • 1h 2min
Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405
Gabrielle Lyon, physician and muscle-centric medicine pioneer, explains why your glutes are a longevity organ. She covers muscle’s role in metabolism, brain health, and resilience. Topics include protein dosing, mitochondria and performance, intermuscular fat, safe strength training strategies, blood flow restriction, and the risks of GLP-1 drugs without attention to muscle.
51 snips
Jan 25, 2026 • 22min
The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404
They dig into how appetite is driven by gut hormones and why willpower and calorie counting fail. The conversation covers reactivating natural satiety signals with protein, fiber and structured meals. Learn how butyrate from resistant starch can trigger GLP-1 and which starch sources to choose. Practical tips include a slow intro protocol, rebuilding the microbiome, and lifestyle support for gut healing.
