The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
51 snips
Jan 25, 2026 • 22min
The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404
They dig into how appetite is driven by gut hormones and why willpower and calorie counting fail. The conversation covers reactivating natural satiety signals with protein, fiber and structured meals. Learn how butyrate from resistant starch can trigger GLP-1 and which starch sources to choose. Practical tips include a slow intro protocol, rebuilding the microbiome, and lifestyle support for gut healing.
36 snips
Jan 23, 2026 • 9min
Biohacking News Weekly Update : 1403
Discover the transformative shift in U.S. dietary policy as real food takes center stage, challenging ultra-processed products. Explore a groundbreaking study where a drug combination significantly extends the lifespan of frail mice, potentially revolutionizing longevity medicine. Learn about innovative tools like ChatGPT Health for tracking your wellness data. Plus, the return of whole milk to school menus sparks debate over nutrition and health for kids. Dive into these engaging discussions for actionable insights on better living!
81 snips
Jan 22, 2026 • 1h 13min
This Brain Trick Feels Like Cheating (Do THIS) : 1402
Dr. David Perlmutter, a board-certified neurologist and bestselling author, delves into the fascinating link between microglial health and brain function. He discusses how mitochondrial conditions impact cognition, emotional regulation, and neurodegeneration. The conversation highlights everyday factors like diet and sleep that influence this dynamic. They explore innovative tools, including GLP-1 drugs and light therapies, to support brain health. The episode also touches on the role of inflammation in impulsivity and the importance of lifestyle choices for optimal brain resilience.
43 snips
Jan 20, 2026 • 43min
Inside the Mind of the Mad Scientist Rewriting Aging : 1401
Dr. Theodore Achacoso, a pioneering physician-scientist in Health Optimization Medicine, shares groundbreaking insights on how cellular stress shapes aging. He explains the critical role of mitochondria in energy and repair, and how interventions like methylene blue can rejuvenate cellular function. The conversation dives into the effects of travel on metabolism, the significance of LDL cholesterol in detoxification, and the balance of fasting and sleep for optimal health. Get ready to rethink aging from the inside out!
56 snips
Jan 18, 2026 • 23min
I Lost 100 Pounds Of Fat By Drinking Fat (Just Do This) : 1400
Discover how a sip of yak butter tea on a Tibetan mountain transformed one person's approach to food and weight loss. Uncover the surprising connection between dietary fats and fat burning, challenging traditional calorie-counting beliefs. Learn practical food swaps for better health, the benefits of intermittent fasting, and why chronic cardio might actually be hindering your progress. Dive into the pivotal role of mitochondria in energy and aging, along with detox strategies to optimize weight loss and overall wellness.
96 snips
Jan 16, 2026 • 46min
The Superbrain Drug Politicians Use To Outsmart Everyone : 1399
In a captivating discussion, David Renteln, Co-founder and CEO of LUCY Nicotine, shares insights on why nicotine, often misunderstood, can actually enhance cognitive performance when used correctly. He explains how absorption speed affects addiction risk and how oral nicotine can boost memory and neuroplasticity. The duo also delves into the benefits of nicotine for learning, the importance of proper dosing, and the future of regulation in harm reduction. Plus, Renteln offers practical tips for integrating nicotine into daily routines and debunks myths surrounding its use.
82 snips
Jan 15, 2026 • 1h 16min
Why 65% of People SUCK at Modern Relationships : 1398
Adam Lane Smith, MA Psych and attachment expert with over 16 years of experience, discusses the complexities of modern relationships. He reveals that approximately 65% of people have insecure attachment styles and how this impacts emotional stability and intimacy. Adam emphasizes the need for real connections over quick fixes, highlighting the role of hormones like oxytocin and vasopressin. He offers practical techniques for nervous system regulation and proposes the importance of intentional communities in fostering secure attachments. His insights aim to reshape the way we approach relationships and personal well-being.
112 snips
Jan 13, 2026 • 1h 16min
The 12 Greatest Mood Boosters on Earth : 1397
Lucas Aoun, a prominent biohacker and founder of Ergogenic Health, reveals powerful mood boosters rooted in biology. He explains how upregulating dopamine receptors can enhance motivation and resilience without reliance on stimulants. The discussion delves into innovative compounds like solbutiamine and lithium orotate for emotional health, while emphasizing lifestyle changes such as exercise and sauna use. They also caution about the impact of GLP-1 drugs on motivation. Expect insights that blend science with practical techniques for mood enhancement.
92 snips
Jan 11, 2026 • 12min
I Cracked The Code To Staying Lean In My 50s (Here's How) : 1396
Discover why 72 hours of fasting might be the key to reversing aging. Dave Asprey explains how typical 16-hour fasts fall short, missing the deeper repair phase your body craves. Learn about the critical role of autophagy in cellular repair and the dangers of common fasting mistakes. He provides insights on what happens physically during a 3-day fast, including ketosis and stem cell activation. Plus, get expert tips on preparing for and breaking a fast to maximize benefits.
34 snips
Jan 9, 2026 • 1h 11min
Reversing The American Food Pyramid | Calley Means : 1395
In this conversation, Calley Means, a passionate entrepreneur and policy advocate for food-system reform, joins Dave Asprey to challenge the traditional American food pyramid. They explore how chronic disease has become a profitable business, driven by ultra-processed food and flawed healthcare incentives. Calley discusses the significance of 'food as medicine,' advocating for changes that allow HSAs to cover healthier options. The duo emphasizes the urgent need for policy reform, personal health autonomy, and the importance of educating individuals to reclaim their health.
