The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
62 snips
Feb 27, 2026 • 9min
Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423
They debate whether epigenetic reprogramming could actually reverse aging in human tissues and what early trials might mean for the field. They unpack a closed, high‑power AI drug design engine and its implications for transparency and access. They highlight a cartel leader’s cache of injectable treatments to show gray‑market risks and sound the alarm on a measles comeback.
70 snips
Feb 26, 2026 • 1h 1min
The Secret to Staying DANGEROUS After 50 : 1422
Jay Campbell, peptide researcher and educator with 10+ years teaching advanced peptide protocols, breaks peptides into plain English. He covers delivery choices like pens and patches, mitochondrial peptides such as elamipretide and MOTS-c, growth hormone options, and a new long‑acting follistatin analog. Practical talk on pharmacokinetics, timing, safety, and real‑world dosing keeps the science usable.
58 snips
Feb 24, 2026 • 57min
The Home Laser That Reverses Skin Age By 20 Years : 1421
Lucy Goff, founder of LYMA and creator of an at-home infrared laser for deep tissue repair. She and Dave discuss how coherent 808nm laser light penetrates deeper than LEDs. Short segments cover safe lens design, gene-expression results including SIRT1 changes, applications for skin, joints, hair and recovery, plus travel and overuse precautions.
42 snips
Feb 22, 2026 • 12min
I Tested The Most Dangerous Viral Brain Hack : 1420
A deep dive into brain fog caused by failing mitochondrial energy and why stimulants only mask the problem. Practical lifestyle levers to protect mitochondria like sleep, light, diet, and toxin reduction. A historical look at methylene blue and how low, careful use can support neuronal energy and neuroprotection. Safety, dosing, interactions, and practical tips for pairing this approach with basic mitochondrial care.
84 snips
Feb 20, 2026 • 11min
Plastic in Your Testicles, AI Sleep Scans, The 29% Weight Loss Drug : 1419
New research finds microplastics inside human testicles and explores how tiny particles may harm male fertility and hormones. A study links fear of aging to faster epigenetic aging through stress and inflammation. A powerful new weight-loss drug produces dramatic body-fat reductions. AI sleep analysis predicts dozens of diseases from one night of sleep, and altitude-inspired biology may improve glucose control.
65 snips
Feb 19, 2026 • 1h 13min
Change Your Morning, Change Your Life – Hal Elrod : 1418
Hal Elrod, author of The Miracle Morning and motivational coach who survived a car crash and cancer, shares his updated SAVERS routine. He discusses customizing morning practices, sleep hacks and evening SLUMBERS, integrating chemo with holistic care, accountability tools and emotional optimization meditation. Short, practical talks on routines, recovery and serving others.
56 snips
Feb 17, 2026 • 1h 7min
The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417
They unpack how falling NAD and stressed mitochondria drive aging signs and low energy. They explore mushroom-derived ergothioneine, olive oil hydroxytyrosol, and why chocolate and creatine appear in formulations. Regulatory and safety questions around NMN and supplement vs pharmaceutical strategies get scrutiny. Practical product choices like dosing, sustainable packaging, and sweetener selection are also discussed.
66 snips
Feb 15, 2026 • 14min
Low Testosterone Starts In Your Eyes (Avoid This Before Bed) : 1416
They explain how testosterone is driven by brain signals during deep sleep, not just age or workouts. The role of slow-wave N3 sleep in hormone pulses gets spotlighted. Common nighttime habits that flatten hormone rhythms are called out. Practical bedtime rules, light management for your eyes, and fixes like warm lighting and screen curfews are recommended.
88 snips
Feb 13, 2026 • 10min
Jet Lag Superdrug, 25% Dementia Drop, Coffee Brain Aging, Kratom Shakeup : 1415
A promising circadian drug that could halve jet lag and speed sleep-wake realignment. New-onset late-life depression framed as an early brain-health signal linked to Parkinson’s and dementia. A long-term brain-training program that cut dementia risk by about 25 percent. Data tying moderate coffee intake to markers of slower brain aging. Regulatory shifts around kratom and what that means for supplement freedom.
64 snips
Feb 12, 2026 • 47min
Turn Off Your WiFi Tonight and See What Happens to Your Sleep : 1414
Katie Mant, BON CHARGE Chief Visionary Officer, a biohacker focused on light and sleep. Andy Mant, BON CHARGE CEO, an EMF and product-design expert. They talk about how blue light and content wreck circadian rhythms. They cover unplugging WiFi at night, EMF mitigation, low-emission product design, red light therapy versus near-infrared, and PEMF mats for recovery.
