The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
87 snips
Mar 12, 2026 • 1h 3min
Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
Dr. Justin Houman, a fellowship-trained urologist and Assistant Professor at Cedars-Sinai specializing in men's health and sexual medicine. He tackles why modern testosterone has collapsed, links low testosterone to mood and metabolic risks, explores fertility-preserving hormone strategies, reviews regenerative penile therapies and shockwave treatment, and recommends lifestyle, drug, and timing hacks for vascular and reproductive health.
40 snips
Mar 10, 2026 • 58min
AI Expert Says: Humans Are Just Mystical Meat Robots : 1429
Tom Griffiths, a Princeton computational cognitive scientist who studies the math behind mind and AI. He and Dave probe how AI reveals quirks of human thought. Short takes on inner speech, mitochondria as energy-driven processors, emotions as computational tools, resource-rational decision-making, and which AI styles avoid messing with your head.
110 snips
Mar 8, 2026 • 10min
How I Finally FIXED My Terrible Sleep After 18 Years : 1428
He reveals that light, not sleep length, was wrecking sleep for 18 years and how sunlight timing resets your internal clock. Discussions cover how blue light at night destroys REM and deep sleep and why morning light kickstarts daytime energy. Practical tips focus on redesigning home lighting, using warm bulbs and blue-blocking glasses, and avoiding weekend sleep shifts that confuse your biology.
140 snips
Mar 6, 2026 • 12min
WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427
Short segments cover diet patterns that add years to life irrespective of genes. Tiny habit stacking in sleep, movement, and food shows big combined mortality benefits. Cutting certain sulfur amino acids may trigger fat browning and thermogenesis. A genetic link between tyrosine and male lifespan raises caution about daily supplements. Doomscrolling about war is flagged as a real health risk.
67 snips
Mar 5, 2026 • 56min
Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426
Josephine Musco, a biodynamic farmer, winemaker, and botanical medicine inventor, explains how micro- and nanoplastics invade brain, blood, hormones, and fat. Short, punchy takes cover how plastics cross barriers, common everyday sources like tea bags and canned food, and practical detox and prevention strategies including lymphatic work, sauna, probiotics, chlorella, and packaging swaps.
88 snips
Mar 3, 2026 • 53min
Why Are Hackers Microdosing “Sex Drugs” Now? : 1425
Dr. Anil Bajnath, a board-certified family physician and founder of the American Board of Precision Medicine, uses multi-omic testing and precision medicine in clinical care. He discusses why population-based medicine fails individuals. Topics include multi-omics, mitochondria and longevity, AI for inflammasome biology, microdosing “sex drugs” for longevity, vagal nerve stimulation and key overlooked biomarkers.
104 snips
Mar 1, 2026 • 15min
A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424
A dive into a surprising lobster-to-human link tied to cellular aging and telomeres. Discussion of why some animals keep regenerating and how humans trade that off for cancer risk. Practical lifestyle pillars for protecting telomeres like sleep, movement, heat and cold exposure, and stress control. A 10-minute daily meditation practice is presented as a simple, drug-free way to activate an anti-aging enzyme.
62 snips
Feb 27, 2026 • 9min
Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423
They debate whether epigenetic reprogramming could actually reverse aging in human tissues and what early trials might mean for the field. They unpack a closed, high‑power AI drug design engine and its implications for transparency and access. They highlight a cartel leader’s cache of injectable treatments to show gray‑market risks and sound the alarm on a measles comeback.
70 snips
Feb 26, 2026 • 1h 1min
The Secret to Staying DANGEROUS After 50 : 1422
Jay Campbell, peptide researcher and educator with 10+ years teaching advanced peptide protocols, breaks peptides into plain English. He covers delivery choices like pens and patches, mitochondrial peptides such as elamipretide and MOTS-c, growth hormone options, and a new long‑acting follistatin analog. Practical talk on pharmacokinetics, timing, safety, and real‑world dosing keeps the science usable.
58 snips
Feb 24, 2026 • 57min
The Home Laser That Reverses Skin Age By 20 Years : 1421
Lucy Goff, founder of LYMA and creator of an at-home infrared laser for deep tissue repair. She and Dave discuss how coherent 808nm laser light penetrates deeper than LEDs. Short segments cover safe lens design, gene-expression results including SIRT1 changes, applications for skin, joints, hair and recovery, plus travel and overuse precautions.
