The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
23 snips
Apr 24, 2026 • 44min
Inside Kambo: Poison, Purging, and The People Who Swear By It : 1455
Caitlin Thompson, a Kambo practitioner and researcher who recovered from Lyme and lupus and now studies this Amazonian medicine. She describes transdermal burns, intense purging, peptide science, and the short window of clarity that follows. They discuss ritual vs clinical practice, safety and sustainability concerns, and why intentional suffering is becoming a tool in functional medicine and resilience work.
49 snips
Apr 23, 2026 • 58min
You've Been Getting Dumber Every Day Since You Turned 30 : 1454
Dr. Tommy Wood, neuroscientist and physician who researches brain optimization, explains why cognitive decline is often self-inflicted. He covers arousal and flow for peak performance, the 3S model (Stimulus, Supply, Support) for long-term brain health, neurostimulation tools, exercise and movement benefits, the risks of constant low-level stimulation, and how to use AI without outsourcing your thinking.
146 snips
Apr 21, 2026 • 1h 1min
Jason Fung: 3 Rules to Lose 50 Pounds Without Ever Counting a Calorie : 1453
Jason Fung, a practicing nephrologist and bestselling author known for work on fasting and metabolic health, explains why hunger — not calories — drives overeating. He explores how ultra-processed foods hijack reward and satiety. He outlines three rules for major weight loss: remove ultra-processed foods, use strategic fasting, and redesign your environment and habits.
101 snips
Apr 19, 2026 • 18min
1 Cup Every Morning Helped Me Lose 100 Pounds (Drink THIS) : 1452
A weight-loss origin story about a daily buttered coffee ritual that sparked dramatic fat loss and energy change. The conversation challenges low-fat dogma, calorie counting, and frequent meals. It spotlights intermittent fasting, saturated fats, plant anti-nutrients, grain and fruit cautions, and why minimal targeted exercise can outperform hours in the gym.
83 snips
Apr 17, 2026 • 11min
Flouride and IQ, Sardinemaxxing, At Home Cancer Cure, Hair Loss Fixes, and more... : 1451
A mix of wild DIY cancer biomedicine and the ethics around access to cutting-edge therapies. New research tying spermidine to fasting benefits and practical tips to boost it. Promising hair-regrowth peptides that may beat minoxidil without systemic risks. A case for sardinemaxxing as a cheap nutrient powerhouse. Reexamination of fluoride and IQ with U.S.-level evidence.
31 snips
Apr 16, 2026 • 37min
Why I'm Putting 100x Bleach on My Face : 1450
Justin Gardner, entrepreneur and regenerative medicine product developer who founded Active Skin Repair to bring medical-grade HOCl to consumers. He explains why hypochlorous acid outperforms common topical antibiotics and peroxide, how it preserves the skin microbiome and healing factors, and practical uses from chronic wounds to eczema. They also cover formulation quality, stability challenges, and pairing HOCl with red light for faster recovery.
44 snips
Apr 14, 2026 • 37min
CDC Director Jim O'Neill on Fixing America's Broken Food Policy : 1449
Jim O'Neill, a public health official and longevity researcher who led SENS Research Foundation and served at HHS and CDC, discusses a federal rewrite of dietary guidelines, new randomized trials on saturated fat, a $144M push for causal aging biomarkers, AI and wearables in medical care, organ bioprinting, GLP-1s and obesity, and reforms to school meals and food-safety oversight.
148 snips
Apr 12, 2026 • 31min
What Doctor's DON'T Tell You About Megadosing Creatine (Over 40) : 1447
They explore creatine beyond bodybuilding, focusing on brain, mitochondrial, mood, bone, and fetal benefits. Myths about safety and sources are debunked. Practical how-tos cover absorption hacks, dosing strategies, forms, and when higher doses might help. Stacking, hydration, methylation cautions, and real-world biohacks for performance and cognition are highlighted.
47 snips
Apr 10, 2026 • 10min
Superhuman Contact Lenses, Motivation Supplement Stack, Cat Scratches Cause Brain Fog, Amino Acid Shortening Lifespan, and more... : 1448
A stealth bacterial infection from cat scratches and flea dirt might explain chronic fatigue and brain fog. New research links high tyrosine to shorter male lifespan and questions common amino acid stacks. Tinted contact lenses that block blue light also cut chromatic aberration and boost visual performance. A taurine plus B‑vitamin stack shows effects on sustained motivation. Simple sensory tricks can reset the nervous system.
46 snips
Apr 9, 2026 • 1h 12min
Why Doctors Can't Fix Women in 2026 : 1446
Dr. Sarah Daccarett, MD, a physician and longevity expert who modernized women's hormone therapy, discusses why legacy hormone approaches fail. She explains vaginal delivery of bioidentical hormones, how low estrogen harms gut, brain, and libido, and why diet alone is not enough. Practical hormone strategies, testosterone nuances, and early testing are covered in a concise masterclass.
