The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
14 snips
Apr 3, 2026 • 54min
Your AC Is Making You Dumber : 1444
Seth Jones, CEO of Superstratum and former musician who turned home detox entrepreneur after building‑related illness. He and Dave dig into how mycotoxins attack mitochondria, disrupt hormones and sleep, why remediation often fails, and practical home detox steps like fogging, HVAC fixes, coatings, and probiotics to protect indoor environments.
17 snips
Apr 2, 2026 • 55min
Your Doctor Is Wrong About Autism (Here's How To Reverse It) : 1443
Tracy Slepcevic, bestselling author, integrative health practitioner and Air Force veteran who rebuilt her son’s life, shares a deep dive into biological roots of autism. She explains environmental triggers meeting genetic susceptibility. Short, focused segments cover gut healing as the foundation, mitochondrial and glial dysfunction, toxins and stem cell approaches that some families have used.
72 snips
Mar 31, 2026 • 1h 2min
Your Organic Protein Powder Is Slowly Killing You : 1441
Oliver Amdrup-Chamby, founder and CEO of PUORI and builder of a rigorously tested supplement brand. They uncover hidden contamination in supplements. They explain oxidized fish oil risks, why organic protein can carry heavy metals, glyphosate binding to collagen, and the value of batch-tested products and the omega-3 index.
62 snips
Mar 29, 2026 • 15min
This Legal Sleep Powder Beats Melatonin Every Time : 1440
A deep dive into why people feel tired but stay wired and how brainwaves, not just chemicals, control sleep. Exploration of beta waves as the sleep blocker and alpha waves as the gateway to rest. Introduction of L-theanine as a non-sedating way to shift brainwaves. Practical tips on light control, timing, and simple evening environment changes to protect sleep.
25 snips
Mar 27, 2026 • 31min
I Injected Stem Cells Into My Penis (Here's What Happened) : 1439
Dr. Victor Urzola, a plastic and reconstructive surgeon and co-founder of RMI Clinic, specializes in regenerative medicine and stem cell therapies. He walks through precision neurocognitive protocols using focused ultrasound, TMS, and targeted stem cell delivery. They also cover plasmapheresis for anti-aging, orthopedic stem cell joint repair, and shockwave plus MSC treatments for sexual and tissue rejuvenation.
79 snips
Mar 26, 2026 • 58min
Arthur Brooks | Why Your Life Has No Meaning : 1438
Arthur Brooks, Harvard professor and bestselling author who studies happiness and leadership, joins to explore why meaning lives in your right brain. He discusses hemispheric lateralization, why tech and optimization can hollow out meaning, and practical paths like meditation, art, and relationship practices that restore right-brain experiences. Short, thought-provoking conversation on consciousness, love, and reclaiming what machines cannot give.
87 snips
Mar 24, 2026 • 56min
This Popular Fat Loss Shortcut Destroys Your Youth : 1437
Hannah Kleinfeld, co-founder and COO of OMNi-BiOTiC US and microbiome expert trained at Yale and Harvard, shares clinical probiotic research and gut-brain insights. She discusses how GLP-1 drugs can cause secondary dysbiosis, why many probiotics fail in stomach acid, and how microbiome shifts affect sleep, HRV, inflammation, hormones, and weight.
108 snips
Mar 22, 2026 • 21min
Give Me 21 Minutes And I'll Give You Perfect Vision Naturally : 1436
A rapid dive into natural vision improvement and why modern life may sabotage eye repair after dark. It explores red light, blueberries, cold exposure, grounding, distance viewing, blink training, and sunset light. The conversation centers on retinal recovery, circadian timing, and daily habits that aim to support sharper eyesight.
56 snips
Mar 20, 2026 • 13min
SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor Stats, Colon Cancer Under 50, and more... : 1435
Comedy sketch targets fringe health culture and what it means when extreme wellness ideas hit the mainstream. New Cornell-linked research spotlights pistachios as a potent whole-food longevity hack. Millions are turning to ChatGPT for health questions, raising safe-use concerns. Gut microbes may matter more for how they organize than which strains are present. Early-onset colon cancer is rising and warrants attention.
50 snips
Mar 19, 2026 • 1h 1min
Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434
McCall McPherson, a physician associate who founded Modern Thyroid Clinic after her own hypothyroidism struggle. She explains why standard testing misses most thyroid issues. Short, sharp takes on T4 versus active T3, why levothyroxine often fails, environmental and dietary triggers, optimal lab panels, and practical next steps for getting the right tests and personalized treatment.
