The Peter Attia Drive

In this episode, Rob Lustig — a researcher, an expert in fructose metabolism, and a former pediatric endocrinologist — discusses what's wrong with the current food environment, and what we can do to reduce our chances of becoming part of the obesity, diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) epidemics. Rob recently earned a Master of Studies in Law because he believes that educating people about sugar from a scientific standpoint is only half the equation: the other half involves changing policy, which he explains in this episode. We discuss: What's the difference between glucose and fructose? [7:00]; Do we have biomarkers that can give us some indication of average exposure to fructose over a given period of time? [14:20]; What's the difference between ALT and AST? [18:45]; Inflammation, endothelial function, and uric acid [21:30]; Is there something that fructose does better than glucose? [23:45]; For children that undergo a remarkable shift from metabolic health to metabolic derangement, is there a concern that these kids suffer an epigenetic hit that makes it harder for them later in life? [26:15]; How many times do you have to introduce a savory food vs a sugary food to an infant before they will accept it? [29:30]; How are alcohol and fructose similar in how they affect the brain? [33:51]; Advice for parents and kids for creating a sustainable environment that's going to prevent them from running into metabolic problems [40:30]; Why do some populations have a higher risk for NAFLD? [45:42]; What causes NAFLD? [48:45]; Is insulin resistance the result of NAFLD or is NAFLD the result of insulin resistance? [56:00]; HRV, cortisol, and norepinephrine [1:00:30]; What are the actual mechanisms that links metabolic syndrome, insulin resistance, fatty liver, and type 2 diabetes? [1:03:00]; Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance? [1:09:00]; What is the difference between soluble and insoluble fiber and why do you need both? [1:13:00]; How can we change the food system when 10 companies control almost 90 percent of the Calories we consume in the US? [1:15:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

This episode explores the question of how we can maintain a naturally youthful look as we get older. Brett — a New York City oculofacial plastic surgeon who specializes in both non-surgical and surgical cosmetic and reconstructive procedures of the eyes and face — shares some remarkably practical advice on everything from the most extensive procedural options, down to the simple steps one can do themselves, starting today, that can make a tremendous impact. Brett also discusses how to pick a provider you trust while you're sorting through the ever-growing list of facial treatments and cosmetic procedures. We discuss: History of medical training that led to Brett's current interests [5:00]; What changes occur that make skin look older over time? [8:00]; How to avoid the "unnatural" look associated with cosmetic surgery [17:00]; Facial augmentation, fixing eye-bags, and picking the right provider [22:15]; Common botox mistakes, and how to do it right [37:30]; Protect and rejuvenate your skin with these 3 main tools [46:30]; Latest trends in cosmetic industry, botox, cryolipolysis, the various forms of facials, and PRP [1:05:00]; Importance of picking a provider you trust, rather than a device you want [1:31:30]; Future of the cosmetic field [1:33:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Corey and Peter met when they visited North Kern State Prison in California together as volunteers for Defy Ventures. Peter was moved by Corey's remarkable story, who is a former inmate himself, and realized he had to have him on the podcast to share his experiences with a wider audience. You'll almost assuredly take away something very important from listening to this episode. Understanding how your experiences can define you, what forgiveness means of both yourself and others, and how good people can do bad things, are just a few of the takeaways. We discuss: How Corey and Peter met through Defy Ventures [4:00]; How Corey's prison experience has shaped his life story [13:30]; Corey's early life, and the traumatic event that changed everything [16:00]; Early adolescence years, beginnings of addiction, and overwhelming shame [23:00]; The 5 ways to classify wounds, and the relationship between trauma and addiction [39:00]; Turbulent high school years, the struggle of parenting a troubled child, and more trauma further shaping the self-narrative [46:00]; Post high school years, spiraling out of control, and giving up on himself [1:02:00]; Navigating prison life, and why a desire to change often isn't enough to make it happen [1:19:00]; The turning point and eventual road to recovery [1:48:00]; 12 step programs: Pros and Cons [1:54:00]; Final days in prison, getting released, and routines Corey has kept [1:54:00] Corey's new perspective on life, takeaways from the visit to Kern prison [2:12:30]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Consider this episode a cross between an ask me anything (AMA) and a show-and-tell. Peter discusses his fasting experiment in great detail and answers questions from listeners and readers. We discuss: Why Peter did a one-week fast and the rationale for front- and back-ending it with a week-long ketogenic diet [6:30]; What Peter's typical diet, exercise, sleep, stress management, and supplementation looks like [11:00]; What labs (e.g., glucose, ketones, lipids, inflammation and oxidation markers, thyroid- and sex hormones) Peter checked for the experiment [22:00]; Peter's results after a week on a ketogenic diet [29:30]; Peter's results after a week on a water-only fast [48:45]; Peter's results after a week on a ketogenic diet following a week of fasting [58:30]; Peter's "Top 6" surprises from the fasting experiment [1:08:30]; Different fasting-mimicking diet (FMD) protocols [1:29:20]; What is the optimal protocol, frequency, and duration for fasting? [1:33:00]; How to break a fast without GI distress? [1:38:00]; "Am I breaking the fast if…?" [1:41:30]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Matt is someone who is deeply interested in understanding the biology of aging. Why do we age? What happens to us as we age? What are the things we can do to slow the aging process? How can we delay or prevent the onset of age-related diseases? These are all questions that Matt thinks deeply about, and explores these questions with his research at the University of Washington. He is currently investigating many of these questions through the Dog Aging Project and the compound rapamycin—the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. We talk about cancer, heart disease, Alzheimer's disease, healthspan, lifespan, and what we can do to provide longer, healthier lives for both people and dogs. We discuss: Matt's early years and his a-ha moment on aging [4:00]; Studying dogs [6:30]; Dogs, rapamycin, and its effects on lifespan and healthspan [15:30]; An unexpected finding in presumably healthy dogs [36:00]; Rapamycin in cancer treatment [50:00]; Why isn't there a rapamycin trial for Alzheimer's disease (AD)? [1:01:30]; If Matt could do a definitive study on life extension in dogs, with resources not being a concern, what does that experiment look like? [1:16:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

In this episode, my good friend David Sabatini delves into his extensive work with the mechanistic target of rapamycin—better known as mTOR—and rapamycin. The compound rapamycin is the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. David, a professor of biology and a member of the Whitehead Institute at MIT, shares his remarkable journey and discovery of mTOR in mammalian cells and its central role in nutrient sensing and longevity. Fasting, rapamycin, mTOR, autophagy, gedankenexperiments: having this conversation with David is like being the proverbial kid in the world's greatest candy store. We discuss: mTOR and David's student years [4:30]; Rapamycin and the discovery of mTOR [8:15]; The connection between rapamycin, mTOR, and longevity [30:30]; mTOR as the cell's general contractor [34:45]; The effect of glucose, insulin, and amino acids on mTORC1 [42:50]; Methionine sensing and restriction [49:45]; An intermittent approach to rapamycin [54:30]; Rapamycin's effects on cancer, cardiovascular disease, and neurodegeneration [57:00]; Gedankenexperiment: couch potatoes on rapamycin vs perfectly behaved humans [1:03:15]; David's dream experiment with no resource constraints [1:07:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Tom Bilyeu is the founder of Impact Theory and a co-founder of Quest Nutrition. In this episode, among the highlights, Tom provides powerful insight he's gained through his pursuit of fulfillment which led to a billion-dollar company in Quest Nutrition. Tom makes a compelling case that it starts with a growth mindset and he's determined to impart this knowledge into as many people as possible. We discuss: Tom's history with dieting and his changing views on fat [4:00]; Tom's dream of immortality [10:00]; Life leading to Quest Nutrition and how "mindset" made the difference [18:45]; Why Tom helped start Quest Nutrition and what made it a success [27:00]; Why Tom started Impact Theory [35:00]; Money and motivation [44:00]; What Tom learned interviewing every employee at Quest, and the one question everyone answers exactly the same [54:15]; Tom's secret formula of fulfillment and the ubiquity of suicide [1:00:00]; Nutrition, fasting, sleep, meditation, and other routines Tom uses to function at his best [1:13:15]; and More Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Pronounced, el-pee-little-a, this lipoprotein is simply described as a low density lipoprotein (LDL) that has an apoprotein "a" attached to it...but Lp(a) goes far beyond its description in terms of its structure, function, and the role that it plays in cardiovascular health and disease. Affecting about 1-in-5 people, and not on the radar of many doctors, this is a deep dive into a very important subject for people to understand. A quick primer on lipoproteins [7:30]; Intro to Lp(a) [11:00]; Lab tests for Lp(a) and reference ranges [20:00]; The physiologic functions of Lp(a) [31:00]; The problems associated with high Lp(a) [34:15]; Lipid-lowering therapies of Lp(a) [44:45]; Lp(a) modification through lifestyle intervention [1:00:45]; High LDL-P on a ketogenic/low-carb-high-fat diet [1:05:30]; and More Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

D.A. Wallach is a true polymath: recording artist, songwriter, essayist, investor, and so much more. In this episode, among the highlights, D.A. provides compelling and colorful insight into how the music industry works today vs the past, liquid biopsies, how to approach healthspan, cancer screening, and how we can reach a "singularity" in medicine. We discuss: How to learn music as a kid and an adult [7:30]; Chester French's early struggles and ultimate success [16:45]; Learning to learn, fostering curiosity in kids, and balancing creativity with structure [31:30]; D.A.'s musical inspirations [44:30]; History of the music industry, Spotify, and other disruptive technologies [50:00]; The past, present, and future of medicine, hospitals, and healthcare [1:05:30]; Investing in health [1:16:30]; What D.A. is most excited about in the future of medicine [1:22:00]; Liquid biopsies, how to make sense of the morass of sensitivity, specificity, positive predictive value, negative predictive value, true negatives, false positives, false negatives, and true positives in cancer screening...and the swiss cheese metaphor [1:33:00]; The immune system, inflammation, and allergies [2:05:45]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Dom digs deep into the research and application of ketogenic diets, exogenous ketones, hyperbaric oxygen treatment, and treating cancer with a metabolic approach. Plus, we lost track of the number of n=Dom experiments mentioned in this episode. We discuss: Dom's early medical training in hyperbaric chambers [7:00]; Effect of ketones on cancer cells [20:00]; Ketones and oxygen toxicity seizures [32:00]; HBOT & its many applications [40:00]; Ketones, MCTs, and exogenous ketones [59:15]; How ketones affect blood glucose [1:20:00]; Ketone esters, salts, enantiomers vs. racemic BOHB [1:38:00]; Dom's ketone tolerance test [1:56:00]; The metabolic management of cancer with a Press-Pulse approach [1:59:45]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.