The Peter Attia Drive #11 - AMA #2: the Nothingburger — results from Peter's week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting
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Aug 23, 2018 AI Snips
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Strict Water-Only Fast Protocol
- During a week-long water-only fast Peter consumed only water, bouillon, and caffeine-free tea; he avoided coffee and sweeteners.
- He experienced very high ketones and near-zero insulin, with marked physiological changes on blood tests.
Fasting Triggers Peripheral Metabolic Shutdown
- Fasting caused a profound peripheral thyroid suppression (free T3 down, reverse T3 up) and a drop in gonadal hormones.
- The body likely downregulated reproduction and metabolic rate as survival responses during starvation.
Uric Acid Spiked After Fasting
- After seven days fasting, uric acid rose markedly (to ~8 mg/dL), possibly reflecting nucleotide/DNA turnover from autophagy.
- This spike might be a candidate marker to study autophagy but needs validation.