Good Medicine Podcast

Alzheimer’s disease has long been defined by cognitive decline. But that way of thinking is changing.In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Brendon Boot from S2N to discuss how the field of Alzheimer’s research has evolved from focusing on symptoms to understanding the underlying changes in the brain.They explore how this shift is influencing regulators, the importance of earlier intervention, and how new therapies could change the way we approach neurodegenerative disease.Dr. Boot also shares how S2N is using naturally occurring Alzheimer’s in dogs as a model for clinical development, and why this approach may help accelerate progress toward human therapies.If early results translate to humans, even partially, this work has the potential to significantly impact how Alzheimer’s is treated in the future.Topics covered include:• The shift from symptom-based to biology-based understanding of Alzheimer’s• Why earlier intervention may be critical for treatment success• Using naturally occurring disease models to advance clinical research🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.NOTE: Dr. Boot misspoke around 22.50. "going to conferences when Leqembi..." he meant to say "going to conferences when Solanezumab...". He requested this get added to the notes for clarity.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: https://www.instagram.com/good.medicine.podcast/X: https://x.com/GoodMedicinePodTikTok: https://www.tiktok.com/@good.medicine.podcastLinkedIn: https://www.linkedin.com/company/goodmedicinepodcast/

Heart disease remains the leading cause of death worldwide, yet many of the biggest risk factors are preventable.In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Troy Badger from CardioStrong to talk about what actually improves cardiovascular health and what people often get wrong when trying to optimize their health.They discuss the importance of lifestyle and fitness for reducing cardiovascular risk, the overwhelming amount of health advice circulating on social media, and why simple habits often matter more than complicated protocols.Dr. Badger shares practical insight from working with patients and athletes on improving long-term health and performance.Topics covered include:• Why lifestyle and exercise remain the most powerful tools for heart health• Navigating misinformation in online health advice• The importance of simplicity in maintaining long-term health🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.Dr. Badger LinkedIn: https://www.linkedin.com/in/troy-badger-md-1313975/CardioStrong Website: https://sparchealthutah.org/Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: https://www.instagram.com/good.medicine.podcast/X: https://x.com/GoodMedicinePodTikTok: https://www.tiktok.com/@good.medicine.podcastLinkedIn: https://www.linkedin.com/company/goodmedicinepodcast/

This week on the Good Medicine Podcast, Dr. David Bearss sits down with Alex Wallberg from SPARC Health to talk about building healthcare startups that actually improve patient outcomes.SPARC Health focuses on helping technical founders navigate the complex world of healthcare innovation by pairing them with experienced mentors, operators, and capital providers who can guide companies through the challenges of building in life sciences and health technology.Alex shares how SPARC works with founders to translate promising ideas into real companies, and why mentorship, community, and strategic support are essential for success in healthcare innovation.The conversation also explores what separates great founders from the rest. Alex emphasizes that the best entrepreneurs keep patients at the center of their mission, while Dr. Bearss notes that when founders focus primarily on money rather than impact, it is often a warning sign.Finally, Alex reflects on the strength of Utah’s life sciences community and why collaboration between entrepreneurs, investors, and operators has become one of the region’s biggest advantages.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠Alex Wallberg LinkedIn: https://www.linkedin.com/in/alex-wallberg/SPARC Health LinkedIn: https://www.linkedin.com/company/sparchealth/SPARC Health Website: https://sparchealthutah.org/

This week on the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Evan Unger, physician-scientist, serial biotech entrepreneur, and pioneer in therapeutic oxygen delivery technologies.Dr. Unger has spent decades working at the intersection of medicine, physics, and innovation. His work has focused on developing technologies that improve how oxygen is delivered to tissues in critical conditions such as cancer and heart attack. Tumor hypoxia, a state where parts of a tumor are deprived of adequate oxygen, has long been recognized as a major barrier to effective radiation therapy. Hypoxic tumors are more resistant to treatment, which can limit outcomes. Dr. Unger discusses why this problem has persisted since it was first described in the 1950s and why he believes his current work may represent one of the first meaningful approaches to reversing tumor hypoxia.The conversation also explores the realities of being an inventor and biotech founder. Dr. Unger reflects on how having too many ideas can become a liability, and why focus, regulatory strategy, market opportunity, and disciplined value creation are essential for translating innovation into impact.Finally, he shares why he remains driven by the possibility that new approaches to oxygen delivery could fundamentally transform treatment for heart attack, still the leading cause of death in the United States. This episode is about persistence, disciplined innovation, and pursuing breakthroughs that could change outcomes at scale.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠

This week on the Good Medicine Podcast, Dr. David Bearss sits down with Olympic gold medalist Peter Vidmar to talk about excellence, discipline, and the lifelong impact of exercise.Peter reflects on his journey to Olympic gold, the influence of a coach who emphasized fundamentals above everything else, and how mastering the basics accelerated his growth. He shares how his love for gymnastics began at a young age and why he never cared whether his peers understood his passion.The conversation also explores Peter’s work with the “Ready, Set, Gold” program, where Olympians partnered with schools to inspire young people to improve their physical fitness. He discusses the powerful connection between physical activity, mental health, and long-term well-being.From elite competition to everyday fitness, this episode is about consistency, discipline, and finding movement that works for you.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠

This week on the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Myles Greenberg, President and CEO of InCarda Therapeutics, to explore the non-traditional path from practicing physician to life sciences executive.With more than 25 years of experience across clinical medicine, venture capital, entrepreneurship, and executive leadership, Dr. Greenberg shares how operating under uncertainty in the emergency room directly prepared him for leading companies through high-stakes decision making.They discuss the realities of clinical trial execution, the challenges of recruiting patients in acute care settings, and why innovation in medicine remains one of the most demanding yet rewarding fields to work in.This episode is about resilience, adaptability, and the drive to solve unmet patient needs at scale.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠

This week on the Good Medicine Podcast, Dr. David Bearss sits down with Josh Miller, CEO of Biologic Input Output Systems, Inc. (BIOS), to talk about groundbreaking work at the intersection of neuroscience, engineering, and human connection.BIOS develops advanced neural interface technology that allows the nervous system to communicate directly with machines. Their work focuses on restoring movement, sensation, and function by translating brain signals into action and, in some cases, returning sensory feedback back to the brain.In this conversation, Josh shares deeply moving stories from clinical trials, including a woman who was able to feel and control a virtual hand simply by thinking about it after years without an arm. He also explains why BIOS chose to start with upper limb prosthetics, one of the most complex challenges in neurotechnology, and what it means for people who have lost the ability to do simple but meaningful things like holding a loved one’s hand.The episode also explores how BIOS technology could help block pain signals in the nervous system, opening the door to entirely new approaches to pain management.This is a conversation about science that restores dignity, independence, and hope.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠BIOSFor individuals interested in connecting directly with BIOS: https://www.biologicinputoutputsystems.com/registryLinkedIn: https://www.linkedin.com/company/biologic-input-output-systems/Instagram: @biologicinputoutputsystemsWebsite: https://www.biologicinputoutputsystems.com

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Jim Hotaling and Dr. Brad Cairns from Paterna Biosciences to talk about a new way of thinking about male infertility.Dr. Brad Cairns explains that in many cases, stem cells themselves are not the root of the problem. Instead, the issue lies in the supporting or chaperoning cells that guide stem cells through normal development. Paterna’s work focuses on restoring that developmental process rather than replacing cells outright.The conversation also explores how Paterna is developing approaches to help men with infertility at many different stages, offering options even when traditional treatments have failed. Dr. Jim Hotaling shares the deeply personal side of this work, reflecting on his role in delivering life altering news to families and how that responsibility drives his commitment to building better solutions.This episode blends cutting edge science with the human reality behind infertility and why progress in this space matters so much.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss take a hard look at Alzheimer’s disease through the lenses of caregiving, economics, and the future of medicine.They discuss the immense burden Alzheimer’s places on families and the economy, why treating the disease after it has fully developed may be too late, and how precision medicine could help identify people at risk long before symptoms appear.The conversation also looks ahead to what the next phase of Alzheimer’s research may focus on, shifting from reacting to damage toward preserving brain function decades earlier. This episode is about understanding the full cost of Alzheimer’s and why prevention may be the most important step forward.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss look ahead to what 2026 could bring for medicine, public health, and drug development.They discuss early data suggesting major reductions in tuberculosis progression, how inflammation may reshape the way we treat cardiovascular disease, and why AI guided precision clinical trials are likely to become the norm. These changes could dramatically reduce cost, speed up development timelines, and improve success rates across medicine.This conversation is about where the field is headed next and why the coming years may look very different from the last decade.Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/littFollow Good Medicine PodcastInsta: ⁠https://www.instagram.com/good.medicine.podcast/⁠ X: ⁠https://x.com/GoodMedicinePod⁠ TikTok: ⁠https://www.tiktok.com/@good.medicine.podcast⁠ LinkedIn: ⁠https://www.linkedin.com/company/goodmedicinepodcast/⁠