Replacing Lost Neurons in Alzheimer’s Disease | Dr. Brendon Boot (S2N)

Alzheimer’s disease has long been defined by cognitive decline. But that way of thinking is changing.

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Brendon Boot from S2N to discuss how the field of Alzheimer’s research has evolved from focusing on symptoms to understanding the underlying changes in the brain.

They explore how this shift is influencing regulators, the importance of earlier intervention, and how new therapies could change the way we approach neurodegenerative disease.

Dr. Boot also shares how S2N is using naturally occurring Alzheimer’s in dogs as a model for clinical development, and why this approach may help accelerate progress toward human therapies.

If early results translate to humans, even partially, this work has the potential to significantly impact how Alzheimer’s is treated in the future.

Topics covered include:

• The shift from symptom-based to biology-based understanding of Alzheimer’s

• Why earlier intervention may be critical for treatment success

• Using naturally occurring disease models to advance clinical research

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NOTE: Dr. Boot misspoke around 22.50. "going to conferences when Leqembi..." he meant to say "going to conferences when Solanezumab...". He requested this get added to the notes for clarity.

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