Modern Healthspan

In this video Dr. Sabatini discusses his recent paper and in particular  how the health of the mitochondria impact the activation of mTOR and how  this is signaled.  Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  Some key references.  The paper discussed in the video.  Genome-wide CRISPR screens reveal multitiered mechanisms through which  mTORC1 senses mitochondrial dysfunction  https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf   Twenty-five years of mTOR: Uncovering the link from nutrients to growth  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism In this video Dr. Sabatini discusses how mTOR impacts lifespan and  whether its actions change with age   Some key references.  Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/   mTOR introduction YouTube Series with Dr. Sabatini https://www.youtube.com/watch?v=EnIerDljc7g https://www.youtube.com/watch?v=defOfBEuw_M https://www.youtube.com/watch?v=tGA9RALG66s

In this video Dr. Sabatini discusses the role of mTOR as the master regulator of the cell and distinguishes between mTORC1 and mTORC2. Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

In this video talks about the biological age measurement in his research  study and also his views on Exercise as an important contributor for  extending healthspan. We also look at a paper by his team which looks in depth at the effects of acute exercise on the biochemistry of the body. https://www.sciencedirect.com/science/article/abs/pii/S0092867420305080 Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department  of Genetics and Director, Center for Genomics and Personalized Medicine  at Stanford University. He is a leader in the field of functional  genomics and proteomics. Seminal findings from the Snyder laboratory  include the discovery that much more of the human genome is transcribed  and contains regulatory information than was previously appreciated, and  a high diversity of transcription factor binding occurs both between  and within species. He has also pioneered the use of different  state-of-the-art “omics” technologies as well as wearable devices for  managing human health.  

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department  of Genetics and Director, Center for Genomics and Personalized Medicine  at Stanford University. He is a leader in the field of functional  genomics and proteomics. Seminal findings from the Snyder laboratory  include the discovery that much more of the human genome is transcribed  and contains regulatory information than was previously appreciated, and  a high diversity of transcription factor binding occurs both between  and within species. He has also pioneered the use of different  state-of-the-art “omics” technologies as well as wearable devices for  managing human health.    In this episode, Dr. Snyder will talk about Ageotypes, defined as the part  of the body where the aging process was most active based on a research  study led by him, which could explain why we age at different rates. The study tracked 106 healthy individuals, aged between 29 and 75,  taking blood and biological samples to investigate each person at a deep  molecular level. They carried out tests at least five times over two  years in order to record any changes, with Dr. Snyder even taking part  as a subject of his own research.    Researchers discovered four “ageotypes,” – defined as the part of the  body where the aging process was most active. Those involved in the  trial tended to age most within the immune system, kidney, liver, or at a  metabolic level.  Ageotypes may provide a molecular assessment of personal aging,  reflective of personal lifestyle and medical history, that may  ultimately be useful in monitoring and intervening in the aging process. Personal aging markers and ageotypes revealed by deep longitudinal  profiling

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.    In this video, Dr. Snyder talks about the projects in his lab looking at COVID-19 and how wearables can help to fight the disease.

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health. In this podcast, Dr. Snyder will discuss with us how commercial wearables can detect a viral infection even before the obvious symptoms appear Some resources for more information on Dr. Snyder: Dr. Synder Book: Genomics and Personalized Medicine: What Everyone Needs to Know https://amzn.to/3309oLD Dr. Snyder’s Lab at Standford University http://med.stanford.edu/snyderlab.html

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.    In this video, Dr. Snyder discusses how we can manage our health with big data.  He uses his personal experience as an example of what we can learn through monitoring our physiological markers.   Some resources for more information on Dr. Snyder: Dr. Synder Book: Genomics and Personalized Medicine: What Everyone Needs to Know https://amzn.to/3309oLD          Dr. Snyder’s Lab at Standford University http://med.stanford.edu/snyderlab.html

Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai’s New Book - https://amzn.to/30MOsGT Aging and Centenarian Studies : This is the part 2 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine. Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.   Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity.   He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Dr. Barzilai’s New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. In this interview Dr. Barzilai discusses his Metformin, rapamycin and the TAME trial, a large scale clinical trial of Metformin to see if it can reduce or delay the effects of aging. Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health.  Products or services mentioned in this video are not a recommendation. Disclosure: Some of the links provided are affiliate links.  Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey talks about why SENS was founder and why the research that the foundation undertakes is not done by other organizations. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging