Modern Healthspan

In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In Episode 6 Dr. Lithgow talks about the latest research that he is doing in his lab, what his personal longevity protocol is as well how we can move forward with making interventions available for aging.   Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.  ***********************************************************************************  If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan

In Episode 5 Dr. Lithgow talks about the different forms of AKG and why  they chose to go with CaAKG. He also touches on the difficulty in doing  the kind of head to head studies that would be able to see if either was  more effective.   Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.   ***********************************************************************************  If you would like to support our channel, we’d love a coffee…thank you!  https://www.buymeacoffee.com/mhealthspan

In Episode 4 Dr. Lithgow talks about , some other potential benefits of AKG rather than extend healthspan and lifespan.   Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.   *********************************************************************************** If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan

In Episode 3 Dr. Lithgow introduces AKG, or Alpha Ketoglutarate and talks about a recent trial that they did with mice. In the trial they  saw both increased lifespan and healthspan, mostly in the female mice.  Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the  Tenovus Award for Biomedical Research.

In the talk Dr. Lithgow discusses the current drugs that are available  along with some of the limitations of the studies that we are currently  doing.    Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the  Tenovus Award for Biomedical Research.  ***********************************************************************************  If you would like to support our channel, we’d love a coffee…thank you!  https://www.buymeacoffee.com/mhealthspan

In Episode 1 Dr. Lithgow talks about his journey to study aging, his  thoughts on why we age and whether there is limit to the age that humans  can live to.    Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.

In this video Dr. Sabatini discusses some of the life style interventions that affect our longevity and his personal regimen. This  is the last episode of Dr. Sabatani Interview Series.   Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism   Some key references.  Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction  https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf   Twenty-five years of mTOR: Uncovering the link from nutrients to growth  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/   mTOR introduction YouTube Series with Dr. Sabatini  https://www.youtube.com/watch?v=EnIerDljc7g  https://www.youtube.com/watch?v=defOfBEuw_M  https://www.youtube.com/watch?v=tGA9RALG66s

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research.  He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism   In this video Dr. Sabatini discusses how diet effects mTOR activation.  He also talks about calorie restriction and intermittent fasting.   Some key references.  Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf   Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

In this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1  and mTORC2 and the rapalogs, drugs which are similar to rapamycin but  may be more clinically effective.    Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism   Some key references.  Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf   Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/   mTOR introduction YouTube Series with Dr. Sabatini  https://www.youtube.com/watch?v=EnIerDljc7g https://www.youtube.com/watch?v=defOfBEuw_M  https://www.youtube.com/watch?v=tGA9RALG66s