Modern Healthspan

In this episode Dr Naiman provides a more practical view on the PE Diet. What P:E ratio we should aim for, what is an optimal protein intake and how to find the P:E ratio for various foods. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices. Dr Naiman's personal site https://tednaiman.com/ The Protein Percent calculator https://www.proteinpercent.com/ Ted Naiman at the Diet Doctor https://www.dietdoctor.com/authors/dr-ted-naiman-md The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8 The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u

In this episode Dr Naiman talks about his personal journey through various diets to his formulation of the PE Diet. Dr Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices. Dr Naiman's personal site https://tednaiman.com/ The Protein Percent calculator https://www.proteinpercent.com/ Ted Naiman at the Diet Doctor https://www.dietdoctor.com/authors/dr-ted-naiman-md

In this episode Dr Cohen talks about the current interventions that he sees as having the most potential but also about the need for precision medicine as there are many causes for Alzheimer's, diabetes etc. and to treat the disease we need to understand the underlying cause. This also would involve changes in the way trials are run, to be able to identify the markers appropriate for each intervention Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this video Dr Cohen talks CohBar, a company that he co-founded with Professor Nir Barzilai and some of the work they are doing, as well as the latest developments in his lab. He also discusses the need for precision medicine in addressing diseases of aging. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this episode Dr Cohen talks about humanin, SHLEP2 and MTOS-c, how these impact our health, how this varies with ethnicity and age. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this episode Dr Cohen talks about SHMOOZE a new MDP that his lab has discovered and recently published a paper on. He also discusses SNPs, mutations in the MOTS-c and Humanin genome which impacts their peptides with knock on effects on diabetes and cognitive decline. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this episode Dr Cohen talks about mitochondria, the discovery of the peptides they create and some of the benefits that they provide. It seems that the micro-proteins are also not only restricted to the mitochondria and are also made in the nucleus. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this episode Dr Cohen talks about why he started studying aging, his views on IGF-1 and his theory of why we age. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/

In this episode Dr Katz talk about how the quality of our food has changed in the past and how the concerns of the younger generation may impact it in the future. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview. Dr Katz's home page https://davidkatzmd.com/ Diet ID https://www.dietid.com/ Dr Catherine Katz food site https://cuisinicity.com/ Find Dr Katz's books on Amazon How To Eat: All Your Food and Diet Questions Answered https://amzn.to/3TiNbkd The Truth About Food https://amzn.to/3ARckLz The Way to Eat: A Six-Step Path to Lifelong Weight Control https://amzn.to/3QT2m27 Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent https://amzn.to/3pQV96w Papers referred to in this series Actual Causes of Death in the United States https://jamanetwork.com/journals/jama/article-abstract/409171 Actual Causes of Death in the United States, 2000 https://jamanetwork.com/journals/jama/article-abstract/198357 The Global Burden of Disease - Lancet web page https://www.thelancet.com/gbd