#408: The Surprising Truth About Metabolomics, Stress, and Slowing Aging (Peptides, Heavy Metals & Foundational Health Secrets) With Gus Vickery

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Jan 30, 2026

Gus Vickery, a physician and longevity clinician who specializes in metabolomics and personalized detox, joins to unpack metabolomic testing of real-world stress and travel. He explores integrating metabolomics with blood and gut data. They cover nutrient depletion, mitochondrial and NAD imbalances, sympathetic dominance and nervous-system tools, peptides and timing, rising heavy metals, and practical detox and supplementation strategies.

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ANECDOTE

Surprising Personal Metabolomics Result

Nathalie ran a Therium metabolomics test after heavy travel and a supplement break and the results surprised her.
The report revealed early biochemical aging signals despite feeling fine, illustrating hidden cellular depletion.

INSIGHT

Metabolome Reveals Upstream Dysfunction

Metabolomics integrates diet, gut, stress, sleep, and exercise into a single biochemical readout.
Gus argues it reveals upstream dysfunctions long before standard blood tests show clinical disease.

ADVICE

Start NAD Repletion With Niacin And NR

Prioritize NAD replenishment starting with adequate dietary niacin before other NAD boosters.
Gus recommended nicotinamide riboside 500 mg as a practical NAD preload for Nathalie's report.

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Today, I'm sitting down with Dr. Gus Vickery, a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you've ever wondered whether skipping your foundational health habits "just for a little while" really matters, you're about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: therio.me/niddam

If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: https://authentichealth.com/precision-health-evaluation/

Episode Timestamps:

Introduction to Longevity Podcast and episode overview ... 00:00:00

Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05

Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02

Nutrient depletion and oxidative stress: critical findings ... 00:18:57

Supplementation essentials for aging well ... 00:27:05

Metabolomics comparison by age group and optimization goals ... 00:29:03

Stacking interventions: why less is more with diagnostics ... 00:31:05

Functional health markers and the value of context ... 00:34:47

Sympathetic dominance, mindset, and impact on longevity ... 00:35:26

Restoring nervous system balance – inner work and tech tools ... 00:42:38

Toxins, heavy metals, and practical detox strategies ... 00:49:11

Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29

Key nutrient deficiencies revealed by metabolomics ... 01:09:15

Genetic and metabolomic tests: what's actionable? ... 01:15:07

Hope for the future: human resilience and expanding technology ... 01:22:24

Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55

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