The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health From Breast Cancer to Bone Health: The Uncharted Territory of HRT & Chronic Diseases in Menopause with Dr. Elizabeth Yurth
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Jan 13, 2024 
Dr. Elizabeth Yurth, a fellowship-trained physician in anti-aging and regenerative medicine, discusses hormone replacement beyond reproduction. She covers estrogen and testosterone for bone, muscle, and heart health. She explains progesterone’s role in joints and pain, hormone metabolism and cancer risk, and barriers to advanced testing and treatments worldwide.
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Why The WHI Panic Misled Hormone Therapy
- The Women's Health Initiative panic conflated progestins with bioidentical progesterone and led to the broad cessation of hormone therapy.
- Dr Elizabeth Yurth explains the WHI used Premarin plus synthetic progestins, which increased cancer signals, while estrogen-alone arms showed lower breast cancer risk.
Arming Patients With Studies When Doctors Say No
- Dr Yurth describes giving patients study abstracts to challenge clinicians who unreasonably stop HRT.
- She notes many doctors rely on training or hearsay and rarely read original studies, so she offers literature to discuss with them.
Test And Improve Estrogen Detox Before Starting HRT
- Test how an individual metabolizes estrogen before and during therapy using dried urine (DUTCH) to assess 2-, 4-, and 16-hydroxylation pathways.
- Improve detox with DIM, I3C, methylation and glutathione so estrogen favors protective 2-hydroxy metabolites over 4-hydroxy DNA-damaging forms.