American Glutton Why Your Body Does Not Want You to Lose Weight
Feb 16, 2026
Dr. Holly Wyatt, an endocrinologist who studies obesity, weight maintenance, and GLP-1 medications, shares clear, research-backed perspectives. She explains why the body defends weight, how metabolism and appetite drive regain, and contrasts losing weight with keeping it off. Practical strategies for stopping or replacing GLP-1s, mindset work, and long-term planning are highlighted.
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How GLP-1 Medications Change Appetite Regulation
- GLP-1 drugs act like a hormone analog that suppresses appetite by sitting on GLP-1 receptors and reducing food noise.
- Holly Wyatt compares them to insulin for some people: they change physiology but don't make everyone identical because obesity is an individual ecosystem.
Ethan's Chronic View Of Weight Management
- Ethan recounts his long-term weight cycling and how he reframed obesity as a chronic, relapsing condition needing daily work.
- He likens ongoing self-management to giving his daughter insulin: necessary ongoing treatment, not a one-time cure.
Prepare A Playbook Before Stopping GLP-1s
- If you plan to stop GLP-1s, replace the medication with concrete strategies: nutrition patterns, physical activity, and mindset work.
- Wyatt's book is a playbook to pick individualized 'plays' ahead of stopping so transition is seamless.