The Rich Somers Report The Science of Staying Young: Biological Aging Explained | Ryan Smith E481
Mar 28, 2026
Ryan Smith, founder of True Diagnostic and longevity entrepreneur who measures molecular biological age. He explains alcohol’s measurable effect on aging. He breaks down organ-specific age tests and how quickly lifestyle changes show up. He covers exercise, diet, psychedelics, peptides, GLP-1s and everyday supplements as tools to shift biological age.
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Test Before And After Short Lifestyle Changes
- Your molecular drinking signal and some organ ages change quickly; test before and after behavior shifts.
- Ryan says liver and drinking scores can shift in weeks and a single post-drink test shows dramatic change.
Big Reversals Happen In Unhealthy Starting Points
- People starting from poor health can reverse decades of biological age quickly.
- True Diagnostic observed up to ~30-year differences between individuals after interventions; larger gains occur when baseline health is worse.
Exercise Is The Biggest Mover For Aging
- Prioritize exercise combining strength training and cardiovascular work to slow aging.
- Strength preserves muscle-to-brain health and HIIT or heart-rate raising activity protects longevity without needing extreme mileage.