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You've seen the headlines. You've watched the celebrities transform. Maybe you've even wondered, quietly, if it could be for you. But what is the science really saying?
This week on Live Well Be Well, I sit down with Dr. Jack Mosley, GP registrar, and author of Food Noise. Jack brings a perspective that is honest, nuanced, and completely free of hype. We get into what these drugs can genuinely do, who they are truly for, and why taking them without lifestyle support is like putting on noise-cancelling headphones without ever learning to listen to yourself.
Here's What We Dive Into:
- Why up to 40% of weight lost on GLP-1 medications can come from lean muscle, not fat, and why that matters more than the number on the scale.
- What "food noise" actually is and why silencing it with medication is only half the story.
- The 80% reality: why most people regain all their weight within 20 months of stopping and what the 20% who don't have in common.
- Why these are not cosmetic medications, who they are genuinely for, and the real risks of microdosing without clinical need.
Love,
Sarah Ann 💛
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Want to put what Jack shared into practice? The Fast 800 combines intermittent fasting, nutrition, and guided lifestyle support in one place. Co-founded by his father Dr. Michael Mosley. Try it free for 7 days:
👉 www.thefast800.com
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This episode is sponsored by:
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If You Enjoyed This Episode, You Might Also Like:
Fat Loss, Metabolism & The Myth Holding You Back | Dr Andy Galpin
https://youtu.be/ZXLWY5HcPXE
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Highlights
00:00:00 Intro00:01:45 The obesity crisis: how we got here and what's driving it
00:04:10 The string test: a simple way to assess your metabolic health
00:06:30 Muscle loss on GLP-1 medications and the stat no one is talking about
00:10:20 Benefits of GLP-1 drugs: heart disease, sleep apnea, and beyond
00:12:00 Food noise explained and how these drugs work like noise-cancelling headphones
00:15:00 GLP-1 and addiction: alcohol, opioids, and the reward system
00:20:30 Side effects, hair loss, and the dangers of unregulated sources
00:23:30 Microdosing Ozempic: what you really need to know
00:35:00 Shame spirals and the role of self-compassion in sustainable change
00:41:00 Managing cravings without medication: urge surfing and habit stacking
00:47:00 Weight regain after stopping: the 20-month reality check
00:50:30 The Mediterranean diet, the 5:2, and the Fast 800 programme
01:05:30 What live well, be well means to Dr. Jack Mosley
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Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition 
