Weight Regain Reality: 80% Rebound by 20 Months

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You've seen the headlines. You've watched the celebrities transform. Maybe you've even wondered, quietly, if it could be for you. But what is the science really saying?

This week on Live Well Be Well, I sit down with Dr. Jack Mosley, GP registrar, and author of Food Noise. Jack brings a perspective that is honest, nuanced, and completely free of hype. We get into what these drugs can genuinely do, who they are truly for, and why taking them without lifestyle support is like putting on noise-cancelling headphones without ever learning to listen to yourself.

Here's What We Dive Into:

- Why up to 40% of weight lost on GLP-1 medications can come from lean muscle, not fat, and why that matters more than the number on the scale.

- What "food noise" actually is and why silencing it with medication is only half the story.

- The 80% reality: why most people regain all their weight within 20 months of stopping and what the 20% who don't have in common.

- Why these are not cosmetic medications, who they are genuinely for, and the real risks of microdosing without clinical need.

Love,

Sarah Ann 💛

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Want to put what Jack shared into practice? The Fast 800 combines intermittent fasting, nutrition, and guided lifestyle support in one place. Co-founded by his father Dr. Michael Mosley. Try it free for 7 days:

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If You Enjoyed This Episode, You Might Also Like:

Fat Loss, Metabolism & The Myth Holding You Back | Dr Andy Galpin

https://youtu.be/ZXLWY5HcPXE

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Highlights

00:00:00 Intro00:01:45 The obesity crisis: how we got here and what's driving it

00:04:10 The string test: a simple way to assess your metabolic health

00:06:30 Muscle loss on GLP-1 medications and the stat no one is talking about

00:10:20 Benefits of GLP-1 drugs: heart disease, sleep apnea, and beyond

00:12:00 Food noise explained and how these drugs work like noise-cancelling headphones

00:15:00 GLP-1 and addiction: alcohol, opioids, and the reward system

00:20:30 Side effects, hair loss, and the dangers of unregulated sources

00:23:30 Microdosing Ozempic: what you really need to know

00:35:00 Shame spirals and the role of self-compassion in sustainable change

00:41:00 Managing cravings without medication: urge surfing and habit stacking

00:47:00 Weight regain after stopping: the 20-month reality check

00:50:30 The Mediterranean diet, the 5:2, and the Fast 800 programme

01:05:30 What live well, be well means to Dr. Jack Mosley

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