The Dr. Gundry Podcast The Hidden Signs of Aging (And How to Slow Them Down) | EP 397.B
23 snips
Apr 2, 2026 They unpack the difference between chronological and biological age and why the latter matters more. The microbiome’s central role in aging gets a deep dive, including gut barrier health and postbiotics. Simple markers like fasting insulin, muscle mass, stool quality, and skin clues are highlighted. Practical, low-cost steps to slow biological aging and movement tips round out the conversation.
AI Snips
Chapters
Books
Transcript
Episode notes
Epigenetic Methylation As An Aging Signal
- DNA methylation (epigenetic) clocks are a promising measure of biological age because methyl groups turn genes on and off.
- Gundry outlines methyl groups (CH3) and notes many people have MTHFR variants affecting methylation.
Protein Folding Shapes Aging Risk
- Protein folding quality is an emerging frontier in aging research because misfolded proteins underlie diseases like Alzheimer's.
- Gundry highlights that folded 3D shapes determine protein activity and dysfunction accelerates aging.
All Aging Begins In The Gut
- The gut microbiome is central to aging; Gundry argues "all aging begins in the gut."
- He cites the Human Microbiome Project and C. elegans studies showing gut barrier integrity controls lifespan.
