The a16z Show
Andreessen Horowitz
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
Episodes
Mentioned books
872 snips
Mar 15, 2026 • 1h 49min
Marc Andreessen on the Mindset of Great Founders — with David Senra
Marc Andreessen, entrepreneur and cofounder of Andreessen Horowitz, reflects on the mindset of ambitious builders. He explores why many founders avoid introspection and the role of drive versus happiness. He traces history, discusses psychedelics and tradeoffs, contrasts founders with managers, and examines how technology and scale reshape industries.
311 snips
Mar 13, 2026 • 28min
Emil Michael: Iran, Anthropic and the Future of AI at the Pentagon
Emil Michael, Undersecretary of Defense for Research and Engineering and Acting Director of the Defense Innovation Unit, explains how he cut 14 tech priorities to six and made applied AI the top focus. He describes AI use cases across enterprise, intelligence, and warfighting. He also exposes vendor-lock risks from past commercial AI contracts and how procurement must speed up and simplify.
624 snips
Mar 12, 2026 • 33min
Palantir CEO Alex Karp on the Zero-Sum AI Race
Alex Karp, cofounder and CEO of Palantir, a leader in defense-focused data and software. He talks about technology’s role in modern warfare. He discusses deterrence and recent geopolitical tensions. He warns Silicon Valley about AI’s political risks and urges founders to engage with the military. He highlights cultivating unconventional, neurodivergent talent as America’s strategic edge.
133 snips
Mar 11, 2026 • 1h 47min
What It Takes to Clear a Million Crimes a Year with Flock Safety's CEO
Garrett Langley, founder and CEO of Flock Safety and an electrical engineer who built license-plate cameras after a neighborhood theft, tells the story behind a company now deployed in thousands of cities. He discusses scaling cameras to drones, real-time 911 integration, AI orchestration for triage, privacy and audit controls, and how hardware, procurement, and legal limits shape city safety tools.
732 snips
Mar 10, 2026 • 41min
The Top 100 Gen AI Consumer Apps
Olivia Moore, partner at Andreessen Horowitz and co-author of the Top 100 AI Apps report, brings data-driven analysis of consumer AI trends. She discusses why ChatGPT remains far larger than competitors. She breaks down how major platforms specialize for different users. She explores global adoption patterns, the rise of agents, and why memory and voice will reshape products.
533 snips
Mar 9, 2026 • 52min
Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity
Andrew Huberman, Stanford neurobiology and ophthalmology professor and popular science communicator. He explores pandemic-driven self-care, the rise and risks of peptides and GLP-1s, wearable sleep and circadian tracking, noninvasive tools to modulate focus and physiology, and how AI could personalize health learning.
762 snips
Mar 6, 2026 • 55min
Atlassian CEO on the SaaS Apocalypse, AI Agents & What Comes Next
Mike Cannon-Brookes, co-founder and CEO of Atlassian, leads the company through AI and product strategy. He discusses the SaaS selloff and which software businesses face AI-driven pricing risk. He reframes software from records to processes and explores where AI agents can be safely inserted. He also tackles trust, design, and how to make AI work for everyday users in enterprise workflows.
528 snips
Mar 5, 2026 • 37min
Ben Thompson: Anthropic, the Pentagon, and the Limits of Private Power
Ben Thompson, founder of Stratechery and noted tech strategist, discusses the Anthropic–Pentagon standoff and his essay 'Anthropic and Alignment.' He explores how powerful AI attracts political and military interest. Short takes cover surveillance risks, chip geopolitics and Taiwan, why governments may coerce private firms, and why legal solutions matter more than private refusals.
406 snips
Mar 4, 2026 • 49min
Deploying AI in Healthcare
Nikhil Buduma, CEO and co-founder of Ambience Healthcare and former Stanford deep learning PhD, talks about applying AI to clinical workflows. He recounts running a medical practice to learn real-world EHR pain points. Conversations cover building EHR-agnostic layers, clinician adoption at academic centers, rapid prototyping, and how AI product and data architectures must evolve to deliver CFO-grade ROI.
896 snips
Mar 3, 2026 • 51min
Ben Horowitz On What Makes a Great Founder
Ben Horowitz, co-founder and general partner at Andreessen Horowitz and veteran founder-CEO, discusses what separates great founders from the rest. He covers why founders lose confidence and accumulate decision debt. He digs into why VP of Sales hires often fail, when founder mode is useful versus harmful, how blunt feedback shapes culture, and what extreme CEOs teach about leadership.
