This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Stephanie Neal Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine. Links for this episode Invitrogen Science Hero Awards 15:05 Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30 Random forests 48:00 Wasps engineer caterpillars (PLoS Genetics) 50:20 Chemokine-adjuvanted SIV DNA vaccine (Mucos Immunol) 1:02:20 Guide to chemokines (pdf) Role for CCR10 in IgA secreting cell accumulation (J Immunol) CCL28 controls IgA plasma cell accumulation (J Exp Med) In vivo electroporation 1:07:25, 1:09:50 Kathy's groan (jpg) Image credit Letters read on TWiV 356 14:55 Weekly Science Picks 1:18:35, 1:45:30 Alan - Plates from Hooke's MicrographiaRich - The Wright Brothers by David McCulloughKathy - Spore evaporation-driven engines (video and article)Dickson - Color variations of Pluto and Lunar total eclipseStephanie - The science of moldy cheese by Carl ZimmerVincent - But Why? Listener Pick of the Week Reed - The Bench Warmers Podcast Send your virology questions and comments to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy. Links for this episode Announcing mSphere 5:50 Leishmania virus influences drug outcome (paper 1, paper 2) 25:15 Human gut virome and microbiome in infants (Nat Med) 46:00 Multiple displacement amplification (Wiki) 46:00 Virome of adult twins (Nature) 49:15 Illumination by Kevin Folta 1:31:00 Folta story at RetractionWatch 1:41:40 Image credit Letters read on TWiV 355 9:40, 1:20:30 This episode is sponsored by ASMGAP 5:00 Timestamps by Jennifer. Thanks! Weekly Science Picks 1:42:20 Alan - Vexed Muddler storeRich - Ivanpah Solar Power FacilityKathy - The real KermitDickson - Animal PortraitsVincent - Adventures of the Regatjes, Vaccines by Susan Nasif Listener Pick of the Week Jacob - Great Wall of China keeps rabbits out Send your virology questions and comments to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus. Links for this episode Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15 Thing a week (Jonathan Coulton, downloads) 23:20 Immortal Life pornographic? Not! (HuffPost) 25:25 Mollivirus sibericum (PNAS) 27:00 Don't worry about Frankenvirus (WashPost) 27:10 We need flu GOF research (article, Wisc State J, Science) 40:35 Isolation of FIV (Science) 50:20 FIV at Cornell Vet 1:06:25 FIV latency (Retrovirol) 1:08:00 FIV-receptor interactions (Curr Op Virol) 1:08:45 Clin aspects FIV infection (Viruses) FIV antivirals (Viruses) 1:10:05 How to treat FIV 1:10:45 Bud's FIV therapy 1;10;50 FIV vectors (CSH Prot) 1:13:50 Lion FIV (Proc Biol Sci) FIV in cat species (J Virol) 1;01;45 ACIP HVP vaccine recommendations (MMWR) 1:28:45 HPV and cancer (CDC) 1:33:45 Cervical cancer screening (pdf, CDC) Letters read on TWiV 354 7:45, 1:17:10 This episode is sponsored by ASMGAP Timestamps by Jennifer. Thanks! Weekly Science Picks 1:40:40 Alan - Experience CuriosityRich - Primrose SchoolKathy - Egg drop solutionsDickson - Dragonflies by Pieter van DokkumVincent - NASA guide to air-filtering houseplants Listener Pick of the Week Amir - Publons (Nature article) Send your virology questions and comments to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles. Links for this episode 28 years of poliovirus shedding (PLoS Path) 36:50 NOT a rare poliovirus (Wash Post) 44:35 Ukraine polio outbreak (ProMedMail) 41:00 Virus particle transfer of cGAMP (Science one, two) 47:50 cGAS on TWiV 222 47:05 Image credit Letters read on TWiV 353 6:30, 1:10:25 This episode is sponsored by ASMGAP 3:10 Timestamps by Jennifer. Thanks! Weekly Science Picks 1:27:50 Alan - Miniature calendarKathy - Dr. Brainlove (prologue, v. 2.0, IndieGoGo)Dickson - The Ph.D. MovieVincent - Ghostery Listener Pick of the Week Ramon - Children dieChris - ASMLive at ICAAC/ICC Send your virology questions and comments to twiv@twiv.tv

Host: Vincent Racaniello Guest: Michele Banks Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art. Links for this episode Michele Banks on Twitter Artologica Michele's blog The Finch and the Pea Joseph Cornell Not Exactly Rocket Science (Ed Yong) Tree of Life (Jonathan Eisen) Home Microbiome Study Kitten Microbiome Project Science Online The Vexed Muddler Luke Jerram A Daily Dish (Klari Reis) Neuroscience art (Greg Dunn) Ai Weiwei Video of this episode - coming soon Video of Michele working in her studio - view at YouTube Send your virology questions and comments to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome. Links for this episode Paula Pitha-Rowe (Balt Sun) Novel poxvirus (CID) H1N1 and gain-of-function debate (mBio) Recoding dengue virus genome (PNAS) Attenuation by dinucleotide frequency change (PNAS) Codon pair and dinucleotide bias not distinguished (PNAS) Codon pair deoptimization artefact of CG/UA change (eLife) Can engineering subdue viral vaccine reversion? (Virus Evol) Attenuation by a thousand cuts (NEJM) Image credit Letters read on TWiV 351 Weekly Science Picks Alan - Genetic roulette Rich - The Huntington Kathy - Simulated vomiting machine (video) Dickson - Last Cassini Saturn flybyVincent - Decaying Still Life (YouTube) Listener Pick of the Week Ken - Cave meterology (Times, Nature) Send your virology questions and comments to twiv@twiv.tv

Host: Vincent Racaniello Guest: Katherine A. High Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders. This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology. Links for this episode Katherine A. High, MD AAV gene therapy for congenital blindness (Sci Trans Med) Gene therapy for hemophilia (Hematol) AAV capsid decoys (Sci Trans Med) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea. Links for this episode Social media specialist position at ASM WHO dismisses Catholic church on vaccine safety U of T Dean resigns over anti-vaccine course (Tor Star) Vaccine Adverse Event Reporting System (VAERS) Countering anti-vaccination attitudes (PNAS) Designer ribosome (Nature) rVSV-EBOV preliminary report (NEJM) rVSV-EBOV phase III interim report (pdf, Lancet) World on verge of Ebolavirus vaccine (WHO) Ebolavirus vaccine in Africa (virology blog) Letters read on TWiV 349 11:55 This episode is sponsored by ASM GAP Weekly Science Picks Alan - Above and BeyondRich - DSCOVR (Dark moon side crossing Earth)Vincent - Stuxnet virus (Wired, YouTube) Listener Pick of the Week Konrad - Stated Clearly Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses. Links for this episode Virology tenure-track position at NCI (pdf) ASM Agar Art Contest Nigeria on brink of polio eradication (Nature) Dengue in Africa (Tyler Sharp) Permissive vaccines and virulence (PLoS Biol) Marek's disease vaccines and virulence (Ed Yong) Image credit Letters read on TWiV 348 This episode is sponsored by ASM GAP Weekly Science Picks Rich - Swan-Ganz catheter (Wiki, video)Vincent - Mobile DNA III Listener Pick of the Week Kevin - Synthetic prions Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus. Links for this episode Virology tenure-track position at NIH (pdf) 7:00 Voinnet investigation is a Swiss Federal secret (twitter) 12:25 Rose rosette disease in Ft. Worth (Star Telegram) 29:35 Rose rosette virus discovered (J Gen Virol) 34:25 Emeravirus (ViralZone) 33:55 Eriophyid mites (MI Botanical Garden) 32:40 Mite vector of rose rosette disease (U Florida) 34:55 Image credit Squirrel bornavirus associated with human encephalitis (NEJM) 38:40 Poll: How do you consume podcasts? 1:21:40 Letters read on TWiV 347 8:10, 59:40 This episode is sponsored by ASM GAP and ICAAC/ICC Time stamps by Jennifer. Thanks! Weekly Science Picks 1:17:05 Alan - National Immunization Awareness Month (Twitter campaign)Rich - Rosie Revere, Engineer by Andrea BeatyVincent - iPhone owns podcasts (9to5Mac) Listener Pick of the Week Sandra - World Zoonoses Day graphicPeter - Mammal-carnivorous plant mutualism (bat and shrew) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv