This Week in Virology

Vincent Racaniello
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Mar 12, 2017 • 1h 48min

TWiV 432: Conjunction junction, what's your function?

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines (paper one, paper two) Gamete fusion protein is type II viral fusogen (paper one, paper two) Image credit Letters read on TWiV 432 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Raspberry pi Kathy - The Worst F%ing Words Ever Dickson - NASA images of climate changeBrianne - How herd immunity works Vincent - Radioactive boars in Fukushima Listener Pick Margaret - DNA socks and gloves Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
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Mar 5, 2017 • 1h 58min

TWiV 431: Niemann-Pick of the weak

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline (pdf) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology (TWiV 332) Basis for increased Ebolavirus glycoprotein activity (Cell Host Micr) Letters read on TWiV 431 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Rich - Germ Theory by Robert P. GaynesAlan - Student Scientist Partnerships Kathy - Symbiartic Dickson - PaleoBioDB Navigator Vincent - Kusama Infinity Room Listener Pick Chaim - How to fight back against the backfire effect Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
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Feb 26, 2017 • 1h 44min

TWiV 430: The persistence of herpesvirus

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Rep) Restarting lytic gene expression (J Virol) Letters read on TWiV 430 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Rich - Vipassana Momma (Dravet Syndrome) Kathy - Landlines Chrome Experiments Dickson - Origami Revolution Vincent - Hunched Over a Microscope Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
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Feb 19, 2017 • 1h 21min

TWiV 429: Zika Experimental Science Team

Host: Vincent Racaniello Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis. Become a patron of TWiV! Links for this episode Badgers Go Viral (TWiV 260) Rhesus macaque model of Zika virus infection (Nat Commun) Heterologous Zika virus protection in macaques (PLoS NTD) ZEST Data Portal This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Send your virology questions and comments to twiv@microbe.tv
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Feb 12, 2017 • 1h 48min

TWiV 428: Lyse globally, protect locally

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection. Become a patron of TWiV! Links for this episode Nido2017 Meeting Superspreader bacteriophages (mBio) Astrocytes, interferon, and viral infection (JCI) Viral disruption of blood brain barrier (Trends Micro) On Warts by Lewis Thomas (pdf) Letters read on TWiV 428 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Skulls Unlimited Rich - Bernard Moss Reflection Kathy - Why vaccines don't cause autism Dickson - Honomobo Vincent - Trump vs FDA Send your virology questions and comments to twiv@microbe.tv
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Feb 8, 2017 • 56min

TWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus

Host: Vincent Racaniello Guest: Vincent Munster At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. Become a patron of TWiV! Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science (TWiM 140) Image credit Send your virology questions and comments to twiv@microbe.tv
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Feb 5, 2017 • 1h 38min

TWiV 427: It was a DURC and UV light

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. Become a patron of TWiV! Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists' march is bad idea (NY Times) GOF moratorium lifted (Archived White House) VSV gene order (PNAS) VSV gene order later (PNAS) Letters read on TWiV 427 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Good Omen miniseries (book) Kathy - How to cure earworms Dickson - Exoplanets orbits Vincent - Outbreak News Today Listener Pick Tom - The Smartest Protester Send your virology questions and comments to twiv@microbe.tv
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Jan 29, 2017 • 1h 50min

TWiV 426: I'm Axl, and I'll be your cervid today

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists March on Washington Spontaneous generation of unique cervid strain (mSphere) Zika virus entry into human glial cells via Axl (Cell Rep) Article collections: PNAS, Cell, Nature, Virology Letters read on TWiV 426 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv. Weekly Science Picks Alan - Deerland by Al Cambronne Dickson - Antarctica's Colorful Underwater World Kathy - You can't unring a bell #1 and #2 Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki) Vincent - Trump Science Advisors, National Parks Won't Be Silenced Listener Pick Stefan - The Vital Question by Nick Lane Kevin - Scientists March on Washington? Dennis - Fractal Tree of Life Send your virology questions and comments to twiv@microbe.tv
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Jan 22, 2017 • 1h 47min

TWiV 425: All picornaviruses, all the time

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens XKCD #242 Thermostable poliovirus empty capsid vaccine (PLoS Path) Switch between viral entry and clearance (Nature) Glass poliovirus by Jason Roberts Letters read on TWiV 425 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv. Weekly Science Picks Alan - Medical lab whirligig Dickson - Antarctica's Colorful Underwater World Kathy - Prince Rupert's drops #1 and #2 Rich - Dylan's 30th - Eric Clapton --Don't Think Twice, It's All Right (The 30th Anniversary Concert Celebration) Vincent - Saving climate data and Public Good and Public Funding of Science Listener Pick Suellen - For the anti-vaccine people Send your virology questions and comments to twiv@microbe.tv
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Jan 15, 2017 • 1h 51min

TWiV 424: FLERVergnügen

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Trudy Rey Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. Become a patron of TWiV! Links for this episode Welcome omega tau to MicrobeTV Register for ASV 2017 Oliver Smithies dies Assays for prions in the blood (one, two) Biosafety working on prions (Michigan State) Marine origin of retroviruses in Palaeozoic era (Nature Comm) Cancer Virus by Dorothy Crawford Adenovirus and obesity (Int J Chronic Dis) Image credit Letters read on TWiV 424 Weekly Science Picks Trudy - Artist Jenni Viljaniemi Alan - Radio Garden Dickson - World's First Green Energy Boat Kathy - mSphereDirect video and web Rich - Deathworld Trilogy by Harry Harrison Vincent - Trump's Vaccine Panel (NYTimes), Offit's Response (Daily Beast), ASM Letter Send your virology questions and comments to twiv@microbe.tv

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