This Week in Virology

Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research. Hosts: Vincent Racanielloand Alan Dove Guests: Nathalie Grandvaux, Craig McCormick, Kate O'Brien, and Ryan Noyce Become a patron of TWiV! Links for this episode TWiV 2018 World Tour CSV 2018 To wheeze or not to wheeze (Lancet Respir Med) Synthetic infectious horsepox (PLoS One) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Stacy Hornerand Ken Stapleford Become a patron of TWiV! Links for this episode TWiV 2018 World Tour RNA modifications go viral(Plos Path) N6-methyladenosinein flavivirus genomes (Cell Host Micr) Chikungunya virus evolution(Cell Host Micr) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. Hosts: Vincent Racanielloand Rich Condit Guests: Sasha Gorbalenya, Jim Hogle, Ann Palmenberg, and Frank van Kuppeveld Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. Hosts: Vincent Racanielloand Rich Condit Guests: Stacey Schultz-Cherry, Douglas Diekema, and Andrew Noymer Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Dummheit (Healthc Policy) Universal influenza vaccine (mBio) Vaccine personal belief exemptions (Ann Rev Pub Health) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola virus contacts(CIDRAP) WHO FAQ Ebola virus vaccine(WHO) Nipah virusoutbreak (CIDRAP) Revealingparasitoid to hyperparasitoid (PNAS) Hyperparasitoidvideo (YouTube) Calcium channeland influenza virus entry (Cell Host Microbe) Letters readon TWiV 495 Weekly Science Picks Alan - National Cryptologic Museum Rich - Science is mostly about staring Dickson - New Zealand gloworms Kathy - Openingof Smithsonian Outbreak; conference advice General ASV Vincent - ICTV online Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium New Ebola virus outbreakin DRC (WHO) Ebola virus case in urban area of DRC(WHO) Ebola virus outbreak not PHEIC(WHO) Ebola virus vaccinearrives in DRC (CIDRAP) Recent Ebola-Makona mutationsdo not alter pathogenesis (Cell Rep) Letters readon TWiV 494 Weekly Science Picks Alan - Happy 35th birthday, PCR Kathy- Everything can be a speaker Vincent - Ocean rise due to rocks(debunked); Gates advises Trump on viruses Listener Pick Noah- David Baltimore on iBiology Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine FDA meeting materials for tecovirimat(FDA) SIGA Briefing Information (pdf) Errata to the SIGA Briefing Information (pdf) Gut immune cells major targets of norovirus infection(Nat Micro) RNAscope(J Mol Diag) Image credit Letters readon TWiV 493 Weekly Science Picks Alan - Personal Finance for PhDsby Emily Roberts Kathy- Optical illusions fool artificial intelligence Rich- 2017-2018 snowfall graphic Dickson- Dust from the Sahara Vincent - The Last Days of Smallpoxby Mark Pallen Listener Pick Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Norovirus outbreaks from nori(Emerging Inf Dis) SHERLOCK(Science) HUDSON(Science) DETECTR(Science) Letters readon TWiV 492 Weekly Science Picks Alan - Decline of local newspapers leaves epidemiologists blind Kathy- Journal oversight, mental health research Rich- The Big Sort: An Insider's Tour of a Recycling Plant Dickson- When Science Meets Art Vincent - A Crack in Creationby Doudna and Sternberg Listener Pick Tom- Trillions Upon Trillions of Viruses Fall From the Sky Each Day Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary historyof RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cells(Science) Letters readon TWiV 491 Weekly Science Picks Alan - Oligodendroglioma in song Kathy- Everything-repellent coating to grime proof phone screens & more Rich- Gaia star map Dickson- Clouds are complicated Vincent - Eradicating polio with a vaccine we must stop using Listener Pick Stephen- Forget the Avengers, it took real heroes to make India polio-free Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV Job Site revamped Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Dick Courtney obit Human cowpox infection(NEJM) Mimivirus encodes fermentation genes(Virology) Letters readon TWiV 490 Weekly Science Picks Kathy- Landscapes that look like another world (but they are from Spain) Rich - Brighton Collaboration; Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?) Dickson- Clouds of Jupiter and EBNA2 and autoimmunity Vincent - More than one-third of graduate students report being depressed (original article) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv