This Week in Virology

Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals. Hosts: Vincent Racaniello and Alan Dove Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cummings School of Veterinary Medicine Influenza virus in North Atlantic grey seals (Emerg Microbes infect) Influenza viruses in Alaskan wild birds (Emerg Inf Dis) Wild bird influenza virus replication in human cells (Infect Genet Evol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town's climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich- NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature) Calicivirus portal - long version (biorXiv) m6A modification and innate response (Nat Immunol) Brianne Barker's immunology course m6A modification and innate response (Genes Dev) Letters read on TWiV 534 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - The Red Queen's Race Card Game Alan- Pentax Papilio II Dickson- Felice Frankel on improving visual side of science Kathy- History of the alphabet chart (free download) usefulcharts.com (see blog, such as Latin Greek Cyrillic Venn Diagram) Vincent - Virology Lectures 2019 Listener Pick Peter- Microbehunter (YouTube, blog, forum) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Jerard Hurwitz age 90 RIP Paul has Measles now in French (virology blog) Chinese plasma virome (Cell) Blood virome of 8000 humans (TWiV 435) Měnglà filovirus from bats in China (Nat Microbiol) How to write a virus name (ICTV) Ortervirales (J Virol) Virologists oppose new definition of virus species (Arch Virol) Ebola sitrep (WHO) Letters read on TWiV 533 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Trying Polar Vortex Experiments at Home Rich- Three Identical Strangers Kathy- Science wear, especially for Valentine's Day (discount) Vincent - State of anti-vaccine movement in US and Top 10 Health Threats for 2019 Listener Pick Amy- If government can't deliver safe vaccines, is it fit to rule? Ted- Understanding Economics of Microbial Threats (pdf) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed ASV in Poland does not let go (Ag Buiten ) Alarming ASF outbreak (Science) African swine fever (Euro Comm) African swine fever review (Vet J) ASF in wild boar (EFSA J) ASF in Belgian wild boar (Dept Env Food Rural Aff) Handbook on ASF in wild boar (Stand Grp Experts) Feral hogs (VA DGIF) Nonhuman morbillivirus with zoonotic potential (J Virol) Letters read on TWiV 532 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Retraction Watch database Rich- "The Mayo Clinic: Faith Hope Science" by Ken Burns Kathy- U-M EEB Photographer at Large contest Vincent - Vaccines: An achievement of civilization Listener Pick David- Useless Knowledge Begets New Horizons Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Patrick Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Cancer virology at Pitt Alice Huang's DI particles (PubMed) Circular DNA tumor viruses make circular RNAs (PNAS) Backsplice Image credit Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – The herd to the rescue Alan – Magic Wings Butterfly Conservatory Dickson – 100,000 Genomes Project Kathy – Your Age on Other Worlds Vincent – Vitamin D and Prevention of Cancer and Cardiovascular Disease Pat – North Korea and Bioweapons Listener Pick Eric – The Molecular Basis of Life Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Steve Goff Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! 🎼 They'll histone you when you start to transcribe, And they'll histone you just for tryin' to get by, So be careful when you uncoat your genome, 'Cause everybody must histone. Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 Histones loaded onto incoming retroviral DNA (Cell Host Micr) NP220 and silencing of incoming retroviral DNA (Nature) HIV-1 and HUSH (TWiV 516) TWiV World Tour 2018 t-shirt Timestamps by Jolene. Thanks! Weekly Science Picks Alan - The Tangled Tree by David Quammen Dickson- Ammonia could power the globe Kathy- Portmanteaux and A.Word.A.Day Vincent - Curioscity Steve- Alice and Bob Meet the Wall of Fire Listener Pick Chaim- Tony Fauci on getting your flu vaccine (mp3) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionator (Anal Bioch) Picornaviral gene order (J Virol) Picornavirus protease discovery (J Virol) Poliovirus processing map (J Virol) Nomenclature of picornavirus proteins (J Virol) Black beetle virus (J Virol) Rhinovirus crystallization (PNAS) Mapping mAb binding sites (J Virol) Replication of animal virus in yeast (PNAS) Roland's last paper (J Virol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 Letters read on TWiV 528 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Pandemic Trail game Rich- On a Bat's Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers Listener Pick Anne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv