This Week in Virology

The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registrationends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agentin birds(Viruses) Novel deltavirus in snakes(mBio) SADS-coronavirusin piglets (Nature) Hosts and sources of endemic human coronaviruses(Adv Virus Res) Image credit Letters readon TWiV 546 Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Weekly Science Picks Alan - Plots of Data visualization tool Rich - How to control the brain; Meet UF Physician Kelly Foote, MD Dickson- Oceanix Kathy- Iceproofing large structures Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo Listener Pick Johyne- NYTimes Mag Lab (sorry, no link) Sheena - History of Vaccines by NPR Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the NEIDL video (YouTube) Timestamps by Jolene. Thanks! Weekly Science Picks Jens - Forvo pronunciation guide Brianne -How long do vaccines last? Alan- How much hotter is your home town than when you were born? Dickson- 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize virus inside cells (virology blog) Image credit Letters read on TWiV 544 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy- Preventing airborne disease (video and primary article) Vincent - The Mueller Report Listener Pick Steve- Vaccine Mythbusting Cyprian- Ten simple rules towards healthier research labs Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - How to Take a Picture of a Black Hole Alan- Jupiter Marbleimage Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut Dickson- Sky-High Stunners Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource Listener Pick Martin- Sydney Brenner passes Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps by Jolene. Thanks! Listener Pick Islam- How to successfully collaborate with industry Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- Where and when to see cherry blossoms Dickson- Nebraska floods Kathy- Peeps fungal infection experiment Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces Listener Pick Sam- STLR conversations Josh- Tree of Life Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Letters read on TWiV 540 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- The Quarters Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video] Dickson- How rats became an inescapable part of city living Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses Vincent - Why "chickenpox parties" are a terrible idea—in case it's not obvious Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants (eLife) Image credit Letters read on TWiV 539 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Why Do So Many Scientists Want to be Filmmakers Alan- Better boarding method airlines won't use Dickson- Mass timber building Kathy- What organisms to study flow chart Vincent - World Pulls Andon Cord on 737 MAX Listener Pick Richard- The Real Cost of Knowledge Islam- 200 icosahedral viruses poster Mike- Post-Doc Me Now Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Wendy Mauryand Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TIM-1 is receptorfor Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death (J Virol) T cells and IL-10 in viral demyelination (J Neuroimmunol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Roald Dahl endorses measles vaccine Viruses encode ribosomal proteins (Nat Commun) Bat influenza virus receptor (Nature) Going to bat for flu research (TWiV 173) Letters read on TWiV 537 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Yes, I'm a Scientist on Twitter. Stop Judging Me. Alan- Impact of vaccines, graphed in heat maps Dickson- Treehoppers Kathy- World watershed maps Rich- Gene Machine by Venki Ramakrishnan Vincent - House hearing on measles outbreak (ASM comment) Listener Pick Jordan- Facebook may remove anti-vaccine recommendations Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv