This Week in Virology

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 28 June 2022 VRBPAC meeting materials (FDA) Don't rush to change COVID vaccines (STAT) Monkeypox situation report #1 (WHO) Letters read on TWiV 917 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956) Kathy – Solargraphic analemmas Rich – Windy (desktop; app) Vincent – Why monkeypox is mostly hitting men who have sex with men Listener Picks Mark – Hand Wash Dance – NHK WORLD-JAPAN Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The next epidemic may be here (STAT) Vaccine availability and coverage among children (CDC) Post-infection health impairments in children & adolescents (Pediatrics) Infection detection using saliva & nasopharyngeal samples (Journal of Medical Virology) Effectiveness of vaccines during Delta dominance (The Lancet) Durability of vaccine against severe outcomes (The Lancet) Don't rush to change COVID vaccines (STAT) Concern in the postvaccination era (Immunity, Inflammation and Disease) Infection rebound after Paxlovid & Molnupiravir (medRxiv) No improvement after Ivermectin usage (ACP) Duration of shedding of virus (New England Journal of Medicine) Infectious viral load vaccinated vs unvaccinated (Nat Med) Thromboprophylaxis reduces thromboembolism (NIH) Multi-lineage neural cell and myelin dysregulation caused by infection (Cell) Association between vaccination and post-acute infection (JAMA) Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 916 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory (pdf) COVID vaccine update for fall (WaPo) Don't rush to change COVID vaccines (STAT) Materials from 28 June FDA advisory meeting (FDA) Monkeypox cases US and Global (CDC) Enteric viruses transmit via saliva (Nature) Letters read on TWiV 915 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild Brianne – Origami antibody and virus Kathy – Turbines resistant to high winds Rich – Obi-Wan Kenobi (TV Series) Vincent – The next epidemic may be here. The US isn't ready for it. Listener Picks David: DALL E 2 Douglas – Jazz Online Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Age as a risk factor for severe disease (NY Times) Omicron boosters for the fall (NPR) Pediatric infection and antibody seroprevalence in Arkansas (PIDS) All-cause US maternal mortality during pandemic (JAMA) Effect of 2-week interruption in methotrexate treatment (The Lancet) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID drug interaction checker (IDSA) Contribute to FIMRC fundraiser at PWB 35:42 Dr. Griffin's treatment guide (pdf) Letters read on TWiV 914 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliovirus in UK sewage (ProMedMail and Science) Poliovirus eradication effort (Science) Long COVID after Delta and Omicron (Lancet) How common is long COVID? (Nature) Immune enhancers as antivirals (Cell Chem Biol) Letters read on TWiV 913 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Count Basie: April in Paris Kathy – Bird aerodynamics & inertia: lay article, video, Nature Rich – NASA Gateway (Thanks Ellis) Alan – Polio Eradication in Nigeria Vincent – The Tyranny of Merit by Michael J. Sandel Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Reinfection outcomes (Research Square) CDC recommends vaccine for young children (CDC) Neurodevelopment outcomes in infants post-infection (JAMA) Efficacy of monoclonal antibodies/antivirals in hamsters (Nature) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID drug interaction checker Rebound phenomenon after PAXLOVID in high-risk persons (IDSA) Hospitalization for infection after PAXLOVID treatment (CDC) Risk of post acute infection with different variants (the Lancet) Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 912 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hepatitis of unknown etiology (MMWR) Clinical recognition of monkeypox (CDC) Epstein-Barr virus nanoparticle vaccine (Cell Rep Med) Minimal impact of mAb therapy on COVID vaccine induced antibodies (Sci Trans Med) Letters read on TWiV 911 Timestamps by Jolene. Thanks! Weekly Picks Brianne – A Frog So Small, It Could Not Frog Kathy – A Grand Night In: The Story of Aardman Rich – Archive Vincent – Bandwagoning by Heran Darwin Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tixagevimab-Cilgavimab for infection prevention (NEJM) Ivermectin for outpatient infection treatment (medRxiv) Symptom rebound after PAXLOVID treatment (IDSA) Bamlanivimab minimally impacts immune response to vaccination (Sci Transl Med) In-hospital morality among infected patients (IDSA) Casirvimab/Imdevimab & Remdesivir for infected B-cell depleted patients (IDSA) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Residual viral antigen in patients post infection (IDSA) Rheumatic symptoms following infection (IDSA) Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 910 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks (TWiV 352) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse model for papillomavirus infection (eLife) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 907 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Microbes Rule! at Liberty Science Center Rich – Artemis I update: Mission diagram, mission in photos, launch dates Vincent – Eco-sustainable 3D printed house – Tecla Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv