This Week in Virology

Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael on Anything but academic (TWiM 145) Development of Tecoviromat (TPOXX) (Antiviral Res) Use of Jynneos vaccine (MMWR) Limitations of Tecoviromat (NEJM) Poliovirus in NYC wastewater (NY Times) Letters read on TWiV 927 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958 Kathy – How the US Postal Service reads terrible handwriting Rich – JWST/chorizo gag Vincent – Bat Conservation Trust Listener Picks Bill – The End of Manual Transmission J – How the Krebs cycle powers life and death – with Nick Lane Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance for prevention & treatment of Monkeypox (CDC) Post-infection symptoms among children and adolescents (CDC) Profiling post-infection syndromes in different variants (medRxiv) Comparison of vaccinia Ankara (MVA) vs intradermal routes of administration (NIH) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Infection in vaccinated individuals treated with or without PAXLOVID (medRxiv) Duration of symptoms with positive rapid antigen after infection (J Virological Methods) Epidemiologic characteristics of Monkeypox (CDC) Sequelae of post-acute infection (ScienceDirect) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 926 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How monkeypox virus spreads (CDC) Vaccination against monkeypox virus (CDC) Monkeypox case trends (CDC) Polio in New York State (NY Dept of Health) Poliovirus in NY wastewater (NBC New York) Marburg disease in Ghana (WHO) Ancient herpesvirus genomes (Sci Adv) Combinations of SARS-CoV-2 vaccines (Cell Rep Medicine) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Everyone Loses on Jeopardy Eventually Kathy – Climate spiral followed by Carl Sagan Rich – Most Popular Desktop Browsers 1993 – 2022 Alan – I Am Promise Vincent – Polio in New York Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection, if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Armchair Expert with Malcolm Gladwell Tecovirimat for treatment of monkeypox (OFID) Safety and acceptance of vaccination after MIS (JPID) Is variant less virulent in solid organ transplant recipients (Transplant Infectious Disease) Masks for prevention of respiratory virus infections (Annals of Internal Medicine) Pre-exposure prophylaxis with Evusheld (CMI) Association between Evusheld administration and infection (CID) Repeat administration of casirivimab and imdevimab well-tolerated (ISID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Viral and symptom rebound in untreated infection (medRxiv) Extended Remdesivir infusion for persistent infection (OFID) Baricitinib in patients admitted with infection (The Lancet) Cognitive Impairment 13 months after hospitalization (OFID) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 924 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events. Hosts: Vincent Racaniello and Brianne Barker Guests: Vincent Munster and Raina Plowright Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novel Hendra virus variant in Australia (Emerg Inf Dis) Nipah virus detection after spillover events (Emerg Inf Dis) Want to prevent pandemics? Stop spillovers (Nature) Ecological countermeasures to prevent zoonoses (Restor Ecol) Land-use induced spillovers (Lancet Planet Health) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox infection in humans (NEJM) Pregnancy outcomes after infection (PLOS ONE) Vaccination intent and belief (Emerging Infectious Diseases) Antiviral drug treatment for non-severe disease (CMAJ) Smoking association with infected hospitalized patients (PLOS ONE) Impact of Paxlovid on negative conversion rates (CID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Safety and efficacy of Molnupiravir (Journal of Medical Virology) Enoxaparin for primary thromboprophylaxis (OVID) Statin and aspirin as therapy in infected patients (BMC) Post-infection conditions among children (JAMA) Symptoms and risk factors for long-term effects (Nature Medicine) Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 922 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Pamela Bjorkman and Andy Mehle Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bjorkman laboratory Mehle laboratory Finding the groove (Nat Immunol) Structure of HLA-A2 (Nat Immunol) Mosaic RBD nanoparticles (Science) Influenza virus PB2 627 (J Virol) ANP32B or not to be (eLife) Influenza virus compartmentalization (Nat Commun) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC's recommendation of Novavax's COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant vaccine boosters trial (medRxiv) Novavax triggers neutralization of variant sub-lineages (bioRxiv) CDC recommends Novavax (CDC) Paxlovid in patients who are immunocompromised and hospitalized (The Lancet) Inhaled Fluticasone for outpatient treatment (medRxiv) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 921 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the long haul (Crooked Timber) Flavivirus-induced skin volatile attracts mosquitoes (Cell) Letters read on TWiV 919 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Redactle Kathy – Kirigami paper replacing plastic bubble wrap Rich – First Images from the James Webb Space Telescope (Gravitational lens; Einstein ring) Vincent – Spotted lanternfly Listener Picks Ann – NASA Engineer Who Made the James Webb Space Telescope Work Sonrisa – Aloft – the pleasures and risks of flying Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox outbreak rapid testing response (CDC) Leading causes of death during pandemic (JAMA) FDA recommends vaccine update (FDA) Antibody evasion by subvariants (Nature) Broadly-Neutralizing antibodies against variants (Frontiers in Immunology) Severe outcomes factors in immunocompromised adults (CDC) Measurement of the burden of hospitalizations (OFID) Vaccine hesitancy among parents (Academic Pediatrics) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Saliva evaluation to improve diagnostics (ASTMH) Oral Sabizabulin for high-risk adults (NEJM) Lower risk of MIS-C in children (CID) Neurovascular injury during infection (Brain) Paul Offit on TWiV 917 Contribute to FIMRC fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 918 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv