This Week in Virology

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Bat gut microbiota and flu infection in mice (Transbound Emerg Dis) Primate hemorrhagic fever-causing arteriviruses (Cell) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March Brianne – Why Chimps and Gorillas Form Rainforest Friendships Rich – Fly Water – FPV to New Depths Alan – The Seven Words You Can't Say on Television, by George Carlin, and its repercussions Angela – Nature's Inspiring Women in Science Award Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US A healthcare-associated infection with monkeypox virus (OFID) Air and surface sampling for monkeypox virus (The Lancet) Misrepresentation & nonadherence in COVID-19 public health measures (JAMA) Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet) PAXLOVID patient eligibility screening checklist (FDA) Evaluation of symptomatic disease rebound following PAXLOVID (CID) Outpatient treatment with Remdesivir in patients at high risk (OFID) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Molnupiravir as early treatment for adults with COVID-19 (SSRN) Outcomes among confirmed cases and matched comparison group in long-COVID (Nature) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 945 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Kathryn Hanley Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) One bite is all it takes (TWiV 587) CREATE-NEO Shifts in Borneo mosquito diversity (Ecosphere) VSV surveillance along Rio Grande (PLoS Path) Virulence a trade-off between transmission and clearance (Viruses) West Nile virus disease indicators (Viruses) Identify mosquito meals by barcoding (Trop Med Inf Dis) SkitoSnack (Sci Rep) Neal Nathanson dies (Baltimore Sun) VRR interview with Neal Nathanson (YouTube) Letters read on TWiV 944 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Car Talk Puzzler Archive Rich – The Molecular Biologist Who Exposed the Soviet Union" by Sean B. Carroll Vincent – NYU Chemistry prof fired because his course was too difficult Listener Pick Jack – The Everything Virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Multi-National Monkeypox outbreak (CDC) Mutation of the Monkeypox Virus (Nature) Occupational infection of Healthcare workers with Monkeypox (CDC) Rates of Monkeypox cases by vaccination status (CDC) Protection of SARS-CoV-2 natural infection against reinfection (CMI) PAXLOVID patient eligibility screening checklist (FDA) Paxlovid reduces COVID19 hospitalizations & deaths (EPIC) Paxlovid rebound in COVID19 (NEJM) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 943 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples. This podcast is not an episode of TWiV, but I thought it would be of interest to listeners. Laurie Garrett and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Coliform testing of water in Florida (YouTube) Declining cost of genome sequencing (Illumina) National wastewater surveillance system (CDC) Advances in detection of viruses in wastewater (Med Express) Wastewater monitoring comes of age (Nature) Monitoring monkeypox virus in wastewater (Med Express) Poliovirus wastewater surveillance in NY (Dept of Health) Wastewater surveillance in NYS (Dept of Health) Estimating norovirus infections through wastewater (Water Res) Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control) Intro music is by Ronald Jenkees Send your questions and comments to twiv@microbe.tv

Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) CDC oversells bivalent booster (Wall St Journal) FDA authorizes bivalent COVID-19 booster Letters read on TWiV 942 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine. Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil. Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System Kathy – Durable antimicrobial coating Rich – One Health Vincent – The works of Dashiell Hammett Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Increase in Acute Respiratory illnesses among children and adolescents (CDC) Estimates of Monkeypox incubation period, generation time, reproduction number (CDC) Rapid increase in suspected SARS-CoV-2 reinfections (CDC) Infection prevention and control recommendations for healthcare providers (CDC) SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC) Breakthrough Infection by variants elicited immune response comparable to vaccine (JID) Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL) Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet) Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Effectiveness of Molnupiravir in high risk patients (CID) Update on Long COVID for primary care (BMJ) Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 941 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab. Hosts: Vincent Racaniello and Dickson Despommier Guest: Eddie Holmes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Novel 2019 coronavirus genome (Virological) Proximal origins of SARS-CoV-2 (Virological and Nature versions) Original paper on new CoV in China that led to genome sequence release (Nature) Reporting on Fauci teleconference (USA Today) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Tom Monath Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Fever by John Fuller (Amazon) Crozet BioPharma Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz – Small Group #3: Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five. Rich – Wilderness Safaris (wiki) Alan – Madhouse at the End of the Earth, by Julian Sancton Vincent – Raymond Chandler and his protagonist Philip Marlowe. Listener Picks Philip – Students bitten by bats inside college residence hall Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt at Vaccinated.US Research assistant position with Amy Rosenfeld (pdf) Public health response to polio in New York (MMWR) Impact of mandatory influenza vaccination (Cambridge Core) Monkeypox in young infant (MMWR) Health care worker exposure to monkeypox virus (MMWR) Monkeypox testing delays (Cambridge Core) Monkeypox in smallpox vaccinated patient (Emerg Inf Dis) Transmission potential of monkeypox virus (Int J Epidemiol) TPOXX trial for monkeypox (ACTG) SARS-CoV-2 subgenomic mRNA detection (J Inf Dis) Quantitative SARS-CoV-2 subgenomic mRNA for Remdesivir treatment (Clin Inf Dis) Anti-spike mucosal IgA (NEJM) BNT262bs against Omicron sublineages (NEJM) Awareness and use of SARS-CoV-2 antivirals (Clin Inf Dis) Comparable outcomes for Bebtelovimab and Nirmatrelvir treatment (J Inf Dis) COVID-19 and Alzheimer's disease (J Alzheimer's Dis) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 938 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv