This Week in Virology

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Cedric Feschotte and John Anthony Frank Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cedric on TWiV 935 Antiviral retroviral protein (Science) Stealing genes, facing consequences (Science) Letters read on TWiV 956 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Wastewater Dashboard Rich – Artemis I Mission; Artemis I launch; Artemis I Map Vincent – Pasta Grammar Listener Picks Rich – Watch a virus in the moments before it attacks Justin – Respiratory syncytial virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Four things to know about RSV (Gates Foundation) The burden of RSV in healthy term-born infants in Europe (The Lancet) Diagnostic accuracy of rapid tests for Ebola (CMI) Accuracy of self-collected swabs for diagnosis of Monkeypox (CID) Tecovirimat is effective against human monkeypox virus in vitro (Nature) Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine) SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases) Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications) Maternal antibody response and transplacental transfer following infection or vaccination (CID) Impact of community masking on COVID-19 (Science) Lifting universal masking in schools (NEJM) Bebtelovimab fact sheet for providers (FDA) Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv) Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ) Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA) PAXLOVID patient eligibility screening checklist (FDA) Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv) Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine) Remdesivir fact sheet for providers (Veklury) Twice daily oral zinc in the treatment of patients with COVID-19 (CID) Cognitive deficits in long COVID-19 (NEJM) Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications) Long-lasting symptoms after an acute COVID-19 Infection (JAMA) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 955 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) ACE2-dependent sarbecovirus in Russian bats (PLoS Path) Letters read on TWiV 954 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula Kathy – APODs Jupiter, Lunar Eclipse Blood Moon, Ice Giant Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life) Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1 Listener Pick Debby – Celebrate Bob McDonald's 30 years as host of Quirks & Quarks Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High demand for Amoxicillin causing shortages amid RSV surge (Washington Post) Epidemiologic and clinical features of children & adolescents with monkeypox (CDC) Low risk of SARS-Cov2 transmission by fomites (IDSA) Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID) Impact of community masking on COVID-19 (Science) Remdesivir fact sheet for providers (Veklury) Protection against Omicron from vaccination & previous infection in prison system (NEJM) Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) Bebtelovimab for high-risk outpatients with COVID-19 (OFID) Imprinted SARS-CoV-2 immunity induces convergent Omicron evolution (bioRxiv) PAXLOVID patient eligibility screening checklist (FDA) Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? (Cell) Bebtelovimab fact sheet for providers (FDA) Modeling the effects of global vaccine sharing on the COVID-19 pandemic (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 953 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Omicron variant reproduction ex vivo (Nature) Clinical outcomes with Omicron (Nat Med) Low neutralizing antibodies induced by bivalent booster (NEJM) Antibody responses to bivalent booster (bioRxiV) Spike T cell responses not enhanced by bivalent booster (Sci Immunol) Pandemic end will not be televised (BMJ) Conflation of infection and disease (Twitter) Timestamps by Jolene. Thanks! Weekly Picks Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan's pick from TWiV 931 The Kissing Bug by Daisy Hernandez Rich – Wilderness Safaris Photographic Competition 2022 Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week Vincent – Andrea Camillieri and his protagonist Inspector Montalbano Listener Pick Frank – Economics for the Future: Beyond the Superorganism Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Influenza incidence and vaccine effectiveness (CDC) Nirsevimab for prevention of RSV (NEJM) Severe Monkeypox in hospitalized patients (CDC) Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) Impact of community masking on COVID-19 (Science) Vaccine elicits protective immunity against sarbecoviruses (Science) Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv) Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv) Long-term gastrointestinal sequelae following COVID-19 (CGH) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Evaluation of an automated text message–based program (JAMA) Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon) PAXLOVID patient eligibility screening checklist (FDA) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 951 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) Creutzfeldt-Jakob disease (Adv Exp Med Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication (CDC) Polio by the numbers (JID) Influenza & COVID-19 vaccination coverage among health care personnel (CDC) Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) Receipt of first & second doses of JYNNEOS vaccine (CDC) Distinguishing SARS-CoV-2 persistence and reinfection (CID) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV) Association between physical activity & vaccination protective effect (BMJ) PAXLOVID patient eligibility screening checklist (FDA) COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation) Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV) Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 949 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

David Quammen returns to TWiV to discuss how he wrote his new book 'Breathless', a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Boston Quammens (TWiV 408) Breathless by David Quammen Spillover by David Quammen Song of the Dodo by David Quammen Timestamps by Jolene. Thanks! Weekly Picks David – Shepherd Brianne – Adventure Aquarium Kathy – DART results (Narrative, images) Rich – "Elementary" TV series Vincent – Stop passing the buck on intro science Listener Pick Rich – Consensus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt at Vaccinated.US Prediction of upcoming global infection burden of Influenza (The LANCET) Severe COVID-19 outcomes after full vaccination (The LANCET) Successful immunomodulators for treatment of COVID-19 (CMI) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID patient eligibility screening checklist (FDA) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 947 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv