This Week in Virology

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Gertrud Radu Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps. Links for this episode: Renato Dulbecco, 1914-2012 (virology blog) William Jarrett, 83 (thanks, Lynn Enquist) Dengue virus infection of mosquitoes alters their behavior (PLoS Path) Does dengue make mosquitoes thirstier for blood? (NY Times) Polydnaviruses of braconid wasps (Science) Making nice with viruses (Science) Viral and wasp genes involved in symbiotic replication (J Virol) Amazing parasitic wasp images The Far Side cartoon on mosquitoes (gif) TWiV on Facebook Letters read on TWiV 179 Weekly Science Picks Gertrud - Bat on a plane! (MMWR)Alan - The Rings of Earth (YouTube)Rich - Giant Magellan telescopeVincent - Hepatitis C new drug pipeline Listener Pick of the Week Ricardo - Evolution: The Natural History of Animal SkeletonsPeter - Self-assembly line (YouTube)

The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue. Links for this episode: 2010 dengue epidemic in Puerto Rico Marshall Islands dengue outbreak (one and two) Photo of Tyler by Loren Rodgers TWiV shout-out by NPR and CIDRAP NSABB reverses decision on H5N1 publication TWiV on Facebook Letters read on TWiV 178 Weekly Science Picks Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)Alan - The Winged Scourge (YouTube)Rich - Deepsea ChallengeVincent - Why did a US advisory board reverse its stance? (Ed Yong) Listener Pick of the Week Sasha - Microfluidic FutureAdam - The ConversationJim - ENIAC Programmers Project

A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland. Links for this episode: Restricted data on H5N1 transmission (Science) Novel bunyavirus in China (NEJM and TWiV 127) Ten things about Schmallenberg virus (Microbiology Bytes) NSABB reverses decision on H5N1 papers (virology blog) TWiV on Facebook Letters read on TWiV 177 Weekly Science Picks Connor - Wellcome Trust Science Writing Prize 2012Vincent - Thoughts on academic scientists giving media interviews

Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more. Links for this episode: More than one way to skin a virus (comments) Aerobie aeropress Papers software Vaccinia movies (one and two) Lloyd Kozloff dies BSL4 facilities TWiV on Facebook Letters read on TWiV 176 Weekly Science Picks Rich - Alan Alda's Flame Challenge (NY Times article, Science editorial)Alan - ChronoZoomVincent - Academic Publishing is Broken by Michael P. Taylor Listener Pick of the Week Joel - Fighting a dengue outbreak by Tyler M. Sharp (parts one and two)Sven-Urban - Fooled by Randomness and The Black Swan by Nassim Nicholas Taleb

Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization. Links for this episode: Herpes encephalitis in children with TRIF deficiency (J Clin Inv) Toll-like receptor and cytosolic pattern recognition receptors Skin responses to influenza microneedle vaccine (mBio) Microneedles Fluzone intradermal influenza vaccine QDot nanocrystal technology TWiV on Facebook Letters read on TWiV 175 Weekly Science Picks Matt - Phage and the Origins of Molecular BiologyAlan - Digital Imagine InstituteVincent - iPad apps Goodreader and Notability Listener Pick of the Week Jane -Smoking Ears and Screaming Teeth by Trevor Norton

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis. Links for this episode: Do pet dogs transmit human norovirus? (J Clin Virol) RNA virus miRNA that mimics oncomiR (PNAS) MicroRNA expression by an RNA virus (PNAS) Lab safety stickers jpg (thanks, Jon!) Amateur virologists (Zimmer, NY Times) Genome at home (Wired) Barbergators sing national anthem (YouTube) TWiV on Facebook Letters read on TWiV 174 Weekly Science Picks Rich - NOAA Buoy DataAlan - Autism's False Prophets by Paul OffitVincent - Media Mining Listener Pick of the Week Mark - How the West fueled the AIDS epidemicHenry - RegenesisRick - Biopunk: DIY scientists hack the software of life by Marcus Wohlsen

The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats. Links for this episode: Seroevidence for human H5N1 infection (Science) Mammalian-transmissible H5N1 (mBio) New information about ferret-adapted H5N1 (NY Times, virology blog) New influenza virus from fruit bats (PNAS) Elsevier abandons open access assault (The Scientist) Le virus le plus dangereux? TWiV on Facebook Letters read on TWiV 173 Weekly Science Picks Ashlee – AskScience (Reddit)Michael - HealthMap (iPhone and Android app)Rich – H5N1 research discussion at ASMBiodefenseAlan – El Yunque National ForestVincent – The Journal of Global Health Listener Pick of the Week Judi – NSF visualization challenge Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss atmicrobeworld.org and tag them with twiv.

Hosts: Vincent Racaniello and Kathy Spindler Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor. Links for this episode: Celsius vs Centigrade Neuropathogenesis during polymicrobial infection (PLoS Pathogens) Tetramer staining (pdf) One TWiV on Facebook Letters read on TWiV 172

Matt joins the TWiVarians to review virus production in single cells and single virion genomics. Links for this episode: H5N1 results will be published (NY Times) Virus production in single cells then and now Single virion genomics (PLoS One) Multiple displacement amplification (Wikipedia) Ranavirus killing turtles, tadpoles in Maryland (Washington Post) Three Dog Night TWiV on Facebook Letters read on TWiV 171

Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more. Links for this episode: Norton Zinder, 83 (Reuters) Jenner's cowpox vaccine paper (Bartleby, Gutenberg) Norovirus VLP vaccine (NEJM) Plant-grown H5N1 VLP vaccine (Reuters, PLoS One) Plant-grown norovirus VLP Hexavalent pediatric vaccine TWiV on Facebook Letters read on TWiV 170