This Week in Virology

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid. Links for this episode Protease essential for influenza pathogenesis in mice (PLoS Path) Rhinovirus uncoating is directional (PLoS Path) Fluorescence correlation spectroscopy Capillary electrophoresis (Wiki) Letters read on TWiV 267 Weekly Science Picks Kathy - Amazing mapsAlan - Florida to NJ in 156 seconds (YouTube)Rich - Whiteout over Great Lakes from SpaceVincent - LORiOLA viral necklaces Listener Pick of the Week Carol - Knit picornavirusRobert - RNA: Life's Indispensible Molecule by James Darnell,and Biochemical Pathways by Michal and Schomburg Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis. Links for this episode We should hunt for viruses in space (New Scientist) I had my DNA picture taken (NY Times) CD4 cell death by pyroptosis (Nature) Abortive HIV infection in lymphoid tissue (Cell) IFI16 sensor required for HIV mediated cell death (Science) PubMed Commons Preferential CTL targeting of Gag (Cell Rep) Exonic transcription protein binding (Science) Letters read on TWiV 266 Video of this episode - view at YouTube Weekly Science Picks Kathy - 17 mundane things, mind blowing viewsAlan - SnowovelVincent - Public's views on human evolution Listener Pick of the Week Emily - Dengue pillow Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013. Links for this episode Antiviral RNAi (TWiV 255, 256, 263) MERS-CoV (TWiV 215, 223, 224, 233, 239, 247, 251, 258) Placental trophoblasts confer viral resistance (TWiV 241) Origin of REV (TWiV 248) Phage T7 gets a cat scan (TWiV 220) It's a cGAS! (TWiV 222) Dual virus-host arms race (TWiV 242) Pandoraviruses (TWiV 246, 261) CMV based SIV vaccine (TWiV 254) Threading the NEIDL Letters read on TWiV 265 Video of this episode - view at YouTube Weekly Science Picks Kathy - Women in ScienceAlan - ContagiumRich - RC helicopter (demo)Vincent - The athletic power of quadcopters Listener Pick of the Week Lindsay - Alcohol consumption and vaccines (Vaccine)Johnye - The Singing Microbiologist Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more. Links for this episode Viral gifts Controlling plant viruses by vector control (Ann Rev Phyto) Flavivirus RNAi suppressor (J Virol) Entre probetas podcast (iTunes) Hedgehog central Reprogramming T cells for leukemia therapy (NEJM) Petri Dish podcast On Your Mind podcast Letters read on TWiV 264 Weekly Science Picks Kathy - Sorting algorithms visualizedAlan - StratodeanRich - Art in Science by Polyxeni PotterVincent - Pixel Genes Listener Pick of the Week Judi - Olympus BioScapes Winner Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Ben tenOever Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice. Links for this episode Virusninja Game of clones (Vax Rep) Game of clones bracket Letters read on TWiV 263 Weekly Science Picks Kathy - The Brain Scoop, esp. Where My Ladies AtAlan - Say 'hi' to a spaceship (YouTube)Rich - Garmin BlueChart Mobile and Active CaptainVincent - Journal boycott (one, two)Dickson - Futurescape TV show Listener Pick of the Week Luis - Spillover by David QuammenKen - Gravity Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guest: Ann Palmenberg Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology. Links for this episode Palmenberg lab website - great resources Genome sequences of all rhinoviruses (J All Clin Imm) Cardioviral poly(C) tracts (Arch Virol Supp) EMCV disruption of nuclear transport (PNAS) Picornavirus protease in replicase gene (J Virol) Bacteriophage Qbeta replicase (J Virol) Thanks to Jordan for the episode title! Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and James Van Etten Guests: Chantal Abergel and Jean-Michel Claverie Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus. Links for this episode Unanswered giant virus questions (Adv Virus Res) Fourth domain of life (Commun Integr Biol) Pandoraviruses (Science) Phaeocystis globosa virus (PNAS) Cafeteria roenbergensis virus (PNAS) Symposium group photo (jpg) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Tom Friedrich, Tony Goldberg, and David O'Connor Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory. Links for this episode A tick in Tony's nose (Am J Trop Med Hyg) Two new SIV from colobus monkeys in Uganda (Biomed Cent) Pegivirus diversity in Uganda (J Gen Virol) Simian hemorrhagic fever virus diversity in African primates (J Virol) Video of this episode - coming soon Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guest: Jaquelin Dudley Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus. Links for this episode Rem signal peptide processing and function (J Virol) MMTV null mice and tumorigenesis (J Virol) Jackie's publications (PubMed) I want my MMTV (TWiV 242) Live at ASV in Madison (TWiV 193) Symbiotic safecrackers (TWiV 154) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus. Links for this episode SARS-like virus in bats binds ACE2 (Nature) Bat SARS-like virus that infects human cells (virology blog) Coronavirus infections update (WHO) Lack of MERS coronavirus antibodies in humans (EID) Mice not susceptible to MERS-CoV (J Gen Virol) MERS-CoV case imported into Spain MERS-CoV like virus in European hedgehogs (J Virol) DPP4 amino acids positively selected in bats (Virol J) Image credit: Richie Frieman Letters read on TWiV 258 Weekly Science Picks Kathy - Optical illusion (YouTube)Alan - AmboceptorMatt - Reply all by Richie Frieman (audio sample)Vincent - The microbiology of beer Listener Pick of the Week Cassie - NeatoShopPeter - Synapse evolution with Seth Grant (BSP 101) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv