This Week in Virology

Host: Vincent Racaniello Guests: Susan Baker and Thomas Gallagher Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses. Links for this episode Papain-like viral proteases (Virus Res) MERS-CoV papain-like protease (Virology) Mouse model for MERS-CoV (PNAS) Receptor and MERS-CoV infection (J Virol) Letters read on TWiV 276 Video of this episode - view at YouTube Weekly Science Picks Vincent - First demonstration of Macintosh, 1984 Listener Pick of the Week Lance - The Signal and the Noise by Nate Silver Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life. Links for this episode Virocentric view of evolution (Curr Op Virol) Proposed order Megavirales (Arch Virol) Pithovirus (PNAS) Selfish virus-like elements (Virol J) Pandoraviruses are derived Phycodnaviruses (Biol Direct) Video of this episode - view below at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces. Links for this episode MERS-CoV in dromedary camels (EID) Virologist Al Kapikian dies Polio-like illness in CA (ProMedMail) Acute flaccid paralysis AFP in India (EID) Enterovirus 68 (MMWR) EV 68 CNS infection (Arch Path Lab Med) Polio-free does not mean paralysis-free (The Hindu) Viruses in 14th century coprolite (AEM) Coprolite and paleofeces Ancient poxvirus (EID) Giant coprolite (WordADay) Letters read on TWiV 274 Weekly Science Picks Alan - The science of science communicationRich - Command and Control by Eric SchlosserDickson - Top 10 plant virusesVincent - Is the Nobel Prize good for science?Kathy - Time to rethink graduate and postdoc education (YouTube) Listener Pick of the Week Jon - Lessons from a Kansas graveyardMike - Cross a fashion designer with a microbiologist Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: W. Ian Lipkin and Thomas Briese Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992. Links for this episode MERS-CoV in dromedary camels (mBio) TWiV 251: Don't kiss the camel TWiV 247: Today's weather in virology TWiV 239: Filterable camels Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection. Links for this episode Interferon lambda and HCV outcome (Cell Host Micr) Laser capture microdissection (Wikipedia) HCV dependent fluorescent reporter (Nat Biotech) Bats and viruses (PLoS Path) White nose syndrome (PLoS Path) Mouse phenome database Letters read on TWiV 273 Weekly Science Picks Rich - Think like a scientist (one, two); Science controversiesDickson - Visualization challenge 2013Vincent - Orphan BlackKathy - Alberta worm invasion project Listener Pick of the Week Timothy - How do vaccines cause autism?Anne - Luke Jerram's glass virusesJim - NLM Communications Engineering BranchSteve - Synapse by synapseJacob - Tiny technology creates a buzz Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene. Links for this episode Toxin delivery to plants by viral capsid protein (Nat Biotech) Pea enation mosaic virus (ViralZone) Image credit: Aphid membrane feeding chamber (Sci Rep) Aphid feeding chamber (YouTube) Parafilm (Wikipedia) Human endogenous retrovirus enhances neural gene (PNAS) Flu, common cold, alternative medicine (NCCAM) Cold vs flu (CDC) Phage hunters Bed bugs and infectious disease (PLoS Path) Letters read on TWiV 272 Weekly Science Picks Alan - Statistical error (Nature)Rich - 12 oldest animal speciesDickson - When liquids collideVincent - HIV denial and just asking questionsKathy - Sun's canyon of fire Listener Pick of the Week Sandra - Women physicists keep female students psychedJudi - HHMI's BiointeractiveJacob - Influenza virus HA Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Ashlee Bennett The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates. Links for this episode Tobacco ringspot virus in honeybees (mBio) Plant virus that switched to vertebrates (PNAS) CDC influenza activity and surveillance With Esmeralda at ASM Biodefense (jpg) Image credit: Virginia Tech Learning Resources Center Letters read on TWiV 271 Weekly Science Picks Alan - Nagasaki bombing (YouTube)Rich - GoPro Red Bull Stratos (YouTube)Dickson - Solar orbsVincent - Socrative Listener Pick of the Week Basel - Pathology course onlineRussell - Sochi 2014: Encyclopedia of spendingYegor - Visual Science Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Hruby and Yoshihiro Kawaoka Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC. Links for this episode ASM Biodefense Meeting Influenza H5N1 transmission (Virus Res) Aerosol transmission of H5N1 virus in ferrets (Nature) Characterization of H7N9 virus from humans (Nature) ST-246 efficacy in primates (AAC) Antiviral options for biodefense (Curr Op Virol) ST-246 safety in humans (Antimicrob Agents Chemother) Gain-of-function experiments (Science) Letters read on TWiV 270 Video of this episode - view at Vimeo Weekly Science Picks Vincent - Quanta MagazineRich - Colour is in the eye of the beholder Listener Pick of the Week Kehau - Beautiful but deadly viruses Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16. Links for this episode IFI16 is a nuclear pathogen sensor (Cell Host Micr) Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS) Acetylation regulates IFI16 location (PNAS) Letters read on TWiV 269 Weekly Science Picks Kathy - Female conveners and speakersAlan - SandgrainsRich - 2013 Lamborghini AventadorVincent - Happy Birthday Mac and 128K Mac teardownDickson - Farmdominion Listener Pick of the Week Peter - The Microscope and The Next Global KillerRichard - Glass viruses Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity. Links for this episode How viruses cause disease (Coursera) How clean is your iPad (Which?) Meeting announcement: From emerging to pandemic viruses CaMV virus factories involved in aphid transmission (J Virol) Caulimovirus (ViralZone) CaMV responds instantly to vector (eLIFE) Aphid acquiring CaMV (J Virol) Bat genomes, flight, and immunity (Science) Letters read on TWiV 268 Weekly Science Picks Kathy - Jean-Luc Doumont (slides, communicating science, website, Scitable)Alan - Wireless thermometerVincent - LORiOLA viral necklaces Listener Pick of the Week Jessica - Knit icosahedronRobert - Practical computing for biologists by Haddock and DunnStephen - Fourteen years of US weather (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv