

Biohacking Beauty: The Anti-Aging Skincare Podcast
Young Goose
Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond "single-molecule" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ.
We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.
We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.
Episodes
Mentioned books

Mar 25, 2026 • 32min
Skin Barrier Protocol: How One Reset Makes Every Other Skincare Step Work
They unpack how stinging, tightness, and temporary glow can actually signal skin barrier damage rather than progress. Learn the biological basics of the stratum corneum and why disrupted lipids stop other products from working. Hear a laser-injury case study, a three-step barrier reset, and tips for when to pause actives versus rebuild resilience.

Mar 18, 2026 • 47min
Sleep Is Skincare: How Timing Unlocks Your Body's Best Skin Repair
Did you know that the most powerful anti-aging protocol isn't about how long you sleep? It's about when. Getting eight hours of sleep for skincare feels like a tough feat to achieve especially when life gets in the way.By understanding how your skin begins its optimal repair time, it’s still possible to achieve the best skin results without the guilt of not sleeping enough.In our quest in finding the best skincare ingredient for our products, we discovered that hours of sleep do matter, but best skin results happen by following the skin’s optimal program sequences for deep repair.We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover how melatonin onset, circadian rhythm, growth hormones, and inflammation play a huge role in giving your skin the environment it needs to do its best work.What's Discussed:(1:54-5:09) Why sleep timing matters more than sleep hours for skin repair(07:01-15:19) The three repair windows your skin depends on every night: melatonin onset, growth hormone pulse, and barrier recovery(05:09-5:55) Why dull skin, slow healing, and crepey eyes are often a timing problem — not a product problem(13:28-17:10) How to build a recovery-first nighttime routine before adding any stimulation(37:47-40:47) The silk vs. cotton pillowcase: Which fabric choice is part of your skincare(43:29-47:36) Supplements that support skin repair at night(17:17-17:30) Red light therapy as the only exception to the no-stacking ruleResources mentioned:Sleep protocol: https://www.younggoose.com/pages/sleep-protocolEpisode with Anastasia (BeautyFascia): https://podcasts.apple.com/us/podcast/anastasia-beauty-fascia-facial-fascia-and-massageEpisode on Face Taping with Olga from Natural Face Bible: https://podcasts.apple.com/us/podcast/real-japanese-face-taping-explained-with-olgaFind more from Young Goose:The Elastin Action Protocol → Engineered for Skin Navigating Elasticity ChangeThe Winter Skin Protocol → Build for How Skin Actually Behaves in WinterVAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincare

Mar 11, 2026 • 59min
Alex Tarnava: What Hydrogen Really Does to Your Skin
Molecular hydrogen is often described as a selective antioxidant, but that framing is incomplete. In this episode, we explore hydrogen as a mitochondrial hormetic signal that can influence redox balance, inflammatory regulation, and adaptive stress pathways. The key distinction is that delivery route changes mechanism. Oral, inhaled, and topical hydrogen act differently in the body, with different kinetics, tissue distribution, and biological implications.We dive deeper into this in the Biohacking Beauty Podcast with Alex Tarnava. We discuss why topical hydrogen is gaining attention for skin outcomes, how gut-mediated signaling may drive systemic effects, and why interpreting evidence requires understanding study design, delivery method, and real-world product variability.WHAT’S DISCUSSED:(04:52) Why hydrogen is not a traditional antioxidant and what that actually means biologically(06:17) How different delivery routes change tissue targeting and systemic signaling(10:09) Why skin aging and inflammatory conditions behave more like a systems problem than a single pathway(15:10) How mild oxidative stress can activate endogenous antioxidant production(16:05) The hidden risk of reductive stress from excessive antioxidant use(17:59) Why inflammation must be regulated rather than suppressed for long-term tissue repair(28:52) The gut-driven mechanisms that may influence visible skin outcomes(29:42) How corporate-owned research and investigator-led studies shape the hydrogen evidence landscape(37:25) Why exaggerated longevity claims distort innovation and erode trust(50:49) The growing issue of counterfeit hydrogen products and what it signals about market maturityFind more from Young Goose:The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Alex Tarnava:Website: https://hydrogenwatertablets.com https://alextarnava.comInstagram: https://www.instagram.com/alextarnava

5 snips
Mar 4, 2026 • 1h 13min
Dr. Scott Sherr: Why Chronic Stress Disrupts Mitochondria and Accelerates Visible Skin Aging
Dr. Scott Sherr, an internal medicine physician focused on mitochondrial health and stress physiology, joins to unpack why chronic stress harms cellular energy and shows up in skin early. They explore the sympathetic spiral of doom, how stress hormones damage mitochondria, why sequencing interventions matters, and practical foundations like sleep, nutrition, and targeted therapies.

19 snips
Feb 25, 2026 • 1h 24min
Anastasia (Beauty Fascia): Facial Fascia and Massage + Lymphatic Drainage for Younger-Looking Skin
Anastasia (Beauty Fascia), a board-certified structural integration therapist who specializes in facial and neck myofascial work. She explores fascia’s role in aging, why under-eye puffiness is often drainage not skin, how massage and posture change tissue over time, and why neck, breathing, and jaw patterns shape facial form. Practical routines and tool guidance round out the conversation.

7 snips
Feb 18, 2026 • 51min
Dr. Jila Senemar, MD: How Early Perimenopause and Insulin Resistance Drive Skin Aging
Dr. Jila Senemar MD, FACOG, menopause specialist and longevity physician with 20+ years' clinical experience. She explains how early insulin resistance can drive inflammation and midsection fat. She challenges the idea that regular periods rule out perimenopause. She highlights strength training, DEXA scans at 40, progesterone for sleep and mood, and framing hormone therapy around longevity.

Feb 11, 2026 • 59min
Jess Kane (BodyBio): How Omega Ratios, Low Fat Diets, and Damaged Cell Membranes Trigger Skin Aging
Jess Kane, Co-owner and CMO of BodyBio and cellular membrane specialist. She unpacks how cell membranes and phospholipids underpin skin barrier, tone, and elasticity. She explains why omega-6:3 balance matters, why most “liposomal” supplements fail to reach cells, and practical cellular-first supplement strategies for healthier-looking skin.

Feb 6, 2026 • 27min
Valentine’s Day Special: Our Top Skincare Recommendations for Each Other as Co-Founders + Life Partners
A co-founder couple swaps skincare picks based on current skin needs and long-term resilience. They highlight methylene blue with red light for mitochondrial energy, layered NAD support for repair, and ectoin for deep hydration and blue-light protection. Retinol limits and peptide alternatives come up, plus post-UV DNA repair strategies and a tetrapeptide/marine algae overnight recovery blend.

Feb 4, 2026 • 1h 9min
Marina Moiseyeva: Skin Detoxification, GLP-1s, and What Actually Drives Facial Aging
Marina Moiseyeva, a functional medicine practitioner and anti-aging nurse practitioner, discusses skin as a detox organ and how topicals and medications raise detox load. She covers sweating, lymphatic movement, GLP-1s and nutrient absorption, and why ‘‘Ozempic face’’ reflects muscle, bone, and nutrient loss rather than fat alone.

Jan 28, 2026 • 1h 10min
Joe Radich (R3 Health): Why Skin Treatments Work Better With Physiological Preparation
Joe Radich, NCCPA board-certified PA and founder of R3 Health, trains clinicians in regenerative medicine and biohacking. He explores how chronic stress, hormones, and metabolic health shape skin regeneration. Short, practical talks cover physiological preparation before procedures, peptides and exosomes as signaling tools, hyperbaric oxygen and IVs for prep, and why sourcing and testing matter for biologics.


